Preview

Bulletin of Siberian Medicine

Advanced search

APPLICATION OF A BIODEGRADABLE MATERIAL FOR BONE REPLACEMENT IN TRAUMATOLOGY

https://doi.org/10.20538/1682-0363-2014-5-209-215

Abstract

20 men (medium age (31.5 ± 13.5) years) were studied. All patients underwent arthroscopic auditing plastic anterior cruciate ligament of the knee. Osteoregeneration dynamics were determined by biochemical testing of blood serum and X-ray computed tomography (CT) of the fracture in 1–4 months after surgery. As a result, an estimation of the bone tissue reparative regeneration according to CT data in 10 patients with a defect of the patella, treated with the material is provided. The obtained results of the clinical study indicate the reparative effect of the biodegradable material for bone replacing on bone regeneration

About the Authors

T. V. Druzhinina
Experimental production workshops of the Federal Medical and Biological Agency, St. Petersburg
Russian Federation
Druzhinina Tatiana V.


K. V. Trofimov
Клиническая больница №81 ФМБА России, Северск
Russian Federation


V. F. Naydanov
Federal Center of Traumatology, Orthopaedics and Prosthetics, Barnaul
Russian Federation
Naydanov Vadim F


A. V. Rostovzev
Clinical Hospital № 81 Federal Medical and Biological Agency, Seversk
Russian Federation
Rostovtsev Alexander V.


D. V. Burkov
Federal Center of Traumatology, Orthopaedics and Prosthetics, Barnaul
Russian Federation
Burkov Dmitry V.


A. V. Zhulyabin
Clinical Hospital № 81 Federal Medical and Biological Agency, Seversk
Russian Federation
Zhulyabin Anatoly V.


A. A. Isupov
Clinical Hospital № 81 Federal Medical and Biological Agency, Seversk
Russian Federation
Isupov Alexey A.


A. V. Verevin
Clinical Hospital № 81 Federal Medical and Biological Agency, Seversk
Russian Federation
Verevin Alexey V.


References

1. Astrand J., Aspenberg P. Topical, single dose bisphospho-nate treatment reduced bone resorption in a rat model for prosthetic loosening. J. Orthop. Res., 2004, vol. 22, no. 2, pp. 244–249.

2. Chen X., Kidder L.S., Lew W.D. Osteogenic protein-1 in-duced bone formation in an infected segmental defect in the rat femur. J. Orthop. Res., 2002, no. 20, pp. 142–50.

3. Convery F.R., Minter-Convery M. Acetabular augmenta-tion in primary and revision total hip arthroplasty with cementless prosthesis. Clin. Orthop., 1998, vol. 252, pp. 167–175.

4. Dickson G., Buchanan F., Marsh D. Orthopaedic tissue en-gineering and bone regeneration. Technol. Health. Care, 2007, no. 15 (1), pp. 57–67.

5. Friess W. Collagen-biomaterial for drug delivery. Eur. J. Pharm. Biopharm., 1998, vol. 45, no. 2, pp. 113–136.

6. Vacanti C.A., Pins G. Cell growth on collagen: a review of tissue engineering using scaffolds containing extracellular matrix. J. Long. Term. Eff. Med. Implants, 1992, vol. 2, no. l, pp. 67–80.

7. Lekishvili M.V., Panasyuk A.F. New bioplastic materials in reconstructive surgery. The Herald of the Russian Acad-emy of Medical Science, 2008, no. 9, pp. 33–36 (in Russian).

8. Druzhinina T.V, Khlusov I.A, Karlov A.V, Popov V.P, Rostovtsev A.V, Maslova O.S. Biochemical markers of re-parative regeneration of bone tissue in healthy residents of Tomsk Oblast. Current issues of radiation, functional and laboratory diagnosis: Proceedings of the Conference. Seversk, 2007. Pp. 21–23 (in Russian).

9. Riggz B.L., Melton L.J. Osteoporosis: etiology, diagnos-tics, treatment: the lane with English. St. Petersburg, Nevsky dialect Publ., 2000. 558 p. (in Russian).

10. Adebanjo O.A., Shankar V.S., Pazianas M., Zaidi A., Simon B., Huang C.L., Zaidi M. Modulation of the osteoclast Ca2+ receptor by extracellular protons: possible linkage between Ca2+ sensing and extracellular acidification. Biochem. Biophys. Res. Common., 1994, vol. 199, pp. 742–747.

11. Hall T.J. Reapraisal of the effect of extracellular calcium on osteoblastic bone resorbtion. Biochem. Biophys. Res. Common., 1994, vol. 202, pp. 456–462.

12. Rifas L., Fausto A., Scott M.J., Avioli V., Welgus H.G. Ex-pression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast – like cells: differentiation is associated with repression of metalloproteinase biosynthesis. Endocrinology, 1994, vol. 134, pp. 213–221.

13. Khlusov I.A., Karlov A.V., Sharkeev Yu.P., Pichugin V.F., Kolobov Yu.R., Shashkina G.A., Ivanov M.B., Legostaeva E.V., Sukhikh G.T. Osteogenic Potential of Mesenchymal Stem Cells from Bone Marrow in Situ: Role of Physico-chemical Properties of Artificial Surfaces. Bull. Exp. Biol. Med., 2005, vol. 140, no. 1, pp. 144–152 (in Russian).

14. Khlusov I.A. The possibilities of physicochemical regula-tion of stem cell pool. Byulleten sibirskoy meditsiny – Bulletin of Siberian Medicine, 2007, vol. 6, no. 1, pp. 7–12 (in Russian).


Review

For citations:


Druzhinina T.V., Trofimov K.V., Naydanov V.F., Rostovzev A.V., Burkov D.V., Zhulyabin A.V., Isupov A.A., Verevin A.V. APPLICATION OF A BIODEGRADABLE MATERIAL FOR BONE REPLACEMENT IN TRAUMATOLOGY. Bulletin of Siberian Medicine. 2014;13(5):209-215. (In Russ.) https://doi.org/10.20538/1682-0363-2014-5-209-215

Views: 918


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-0363 (Print)
ISSN 1819-3684 (Online)