QUALITY OF LIFE IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME: INTERRELATION WITH MARKERS OF SYSTEMIC INFLAMMATION
https://doi.org/10.20538/1682-0363-2013-6-5-11
Abstract
Object of research: to study the interrelation of activity of systemic inflammatory response and quality of life (QOL) and evidence of metabolic disorders in hypertensive patients with metabolic syndrome (MS).
Material and methods. We carried out a study of 86 patients with hypertensive disease of II stage in combination with MS and 18 volunteers, who formed the control group. Along with a complete clinical, laboratory and instrumental examination, taken in a specialized cardiology clinic, the study of QOL using the MOS SF-36 questionnaire was carried out, as well as the research of activity of systemic inflammato-ry response.
Results. We determined the reverse correlative interrelation of QOL indicators with all MS components, such as abdominal obesity, hyperglycemia, hypertriglyceridemia, the degree of arterial hypertension, but also with the level of markers of systemic inflammation (C-reactive protein, neopterin and fibrinogen), hyperinsulinemia and hyperleptinemia. It was found out that physical functioning (PF) has the strongest interrelations with the maximum number of clinical and laboratory indicators of MS and all the studied markers of systemic inflammation.
About the Authors
I. D. Bespalova
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
V. A. Bychkov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
V. V. Kalyuzhin
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
N. V. Ryazantseva
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Yu. A. Medyantsev
Tomsk Central Regional Hospital, Tomsk
Russian Federation
Russian Federation
I. A. Osikhov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
B. Yu. Murashev
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
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Review
For citations:
Bespalova I.D., Bychkov V.A., Kalyuzhin V.V., Ryazantseva N.V., Medyantsev Yu.A., Osikhov I.A., Murashev B.Yu. QUALITY OF LIFE IN HYPERTENSIVE PATIENTS WITH METABOLIC SYNDROME: INTERRELATION WITH MARKERS OF SYSTEMIC INFLAMMATION. Bulletin of Siberian Medicine. 2013;12(6):5-11. (In Russ.) https://doi.org/10.20538/1682-0363-2013-6-5-11
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