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ATYPICAL FORMS OF MULTIPLE SCLEROSIS IN THE TOMSK REGION

https://doi.org/10.20538/1682-0363-2013-5-13-17

Abstract

The study involved 280 patients aged 10 to 70 years old with a valid diagnosis of multiple sclerosis according to the McDonald criteria. There  are 6 (2.1%) patients had the first manifestation of disease overthe age of 45, 18 (6.4%) – 20 years earlier. In 7 (2.5%) of patients diagnosed with malignant progressof the MS, in 30 (10.7%) – soft progress.

About the Authors

V. M. Alifirova
Siberian State Medical University, Tomsk
Russian Federation


M. A. Titova
Siberian State Medical University, Tomsk
Russian Federation


E. V. Terskikh
Siberian State Medical University, Tomsk
Russian Federation


N. F. Musina
Siberian State Medical University, Tomsk
Russian Federation


References

1. Schmidt T.Ye., Yakhno N.N. Multiple sclerosis: a guide for physicians. Moscow, MEDpress-Inform Publ., 2010. 272 p. (in Russian).

2. McDonald W.I., Comston A., Edan G. et al. Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann. Neurol., 2000, vol. 50, pp. 121–127.

3. Polman C.H., Reingold S.C., Banwell B., et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann. Neurol., 2011, vol. 69 (2), pp. 292–302.

4. Cazzullo C.L., Ghezzi A., Marforio S. et al. Clinical picture of multiple sclerosis with late onset. Acta. Neurol. Scand., 1978, vol. 58, pp. 190–196.

5. Thompson A.J., Montalban X., Barkhof F. et al. Diagnostic criteria for primary progressive multiple sclerosis: a position paper. Ann. Neurol., 2000, vol. 47, pp. 831–835.

6. Kis B., Rumberg B., Berlit P. Clinical characteristics of patients with late-onset multiple sclerosis. J. Neurol., 2008, vol. 255, pp. 697–702.

7. Amato M.P., Goretti B., Ghezzi A., et al. Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-up. Neurology, 2010, vol. 75 (13), pp. 1134–1340.

8. Lu T., Pan Y., Kao S.Y. et al. Gene regulation and DNA damage in the ageing human brain. Nature, 2004, vol. 429, pp. 883–891.

9. Sim F.J., Zhao C., Penderis J., et al. The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation. J. Neurosci., 2002, vol. 22, pp. 245–249.

10. Wolfson C., Wolfson D.B. The latent period of multiple sclerosis: a critical review. Epidemiology, 1993, vol. 4, pp. 464–470.

11. Haines J.L., Ter-Minassian M., Bazyk A., et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex: the Multiple Sclerosis Genetics Group. Nat. Genet., 1996, vol. 13, pp. 469–471.

12. Hooge J.P., Redekop W.K. Multiple sclerosis with very late onset. Neurology, 1992, vol. 42, pp. 1907–1910.

13. Noseworthy J., Paty D., Wonnacott T. et al. Multiple sclerosis after age of 50. Neurology, 1983, vol. 33, pp. 1537–1544.

14. Polliack M.L., Barak Y., Achiron A. Late onset multiple sclerosis. J. Am. Geriatr. Soc., 2001, vol. 49, pp. 168–171.

15. Frischer J.M., Bramow S., Dal-Bianco A., et al. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain, 2009, vol. 132, pp. 1175–1189.


Review

For citations:


Alifirova V.M., Titova M.A., Terskikh E.V., Musina N.F. ATYPICAL FORMS OF MULTIPLE SCLEROSIS IN THE TOMSK REGION. Bulletin of Siberian Medicine. 2013;12(5):13-17. (In Russ.) https://doi.org/10.20538/1682-0363-2013-5-13-17

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ISSN 1682-0363 (Print)
ISSN 1819-3684 (Online)