A GENERAL MODEL FOR UNIFICATION OF THE THREE PROCESSES OF SLEEP-WAKE REGULATION
https://doi.org/10.20538/1682-0363-2013-2-266-274
Abstract
The most-known model of sleep-wake regulation includes different formulae describing the kinetics of three separate processes, i.e., homeostatic, circadian, and ultradian. We tried to explain all these processes within a more parsimonious modeling framework and to use the EEG recordings of baseline night sleep for derivation of the model’s parameters and for prediction of the effects of experimental manipulations with sleep-wake regimen.
About the Authors
A. A. Putilov
Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk
Russian Federation
Putilov Arkady A. - Laboratory of Mathematical Modeling of Biomedical Systems
Russian Federation
Putilov Arkady A. - Laboratory of Mathematical Modeling of Biomedical Systems
Ye. G. Verevkin
Institute of Molecular Biology and Biophysics SB RAMS, Novosibirsk
Russian Federation
Verevkin Yevgeny G. - Laboratory of Mathematical Modeling of Biomedical Systems
Russian Federation
Verevkin Yevgeny G. - Laboratory of Mathematical Modeling of Biomedical Systems
References
1. Achermann P., Borbely A.A. Simulation of human sleep: ultradian dynamics of electroencephalographic slow-wave activity. J. Biol. Rhythms, 1990, vol. 5, pp. 141–157.
2. Achermann P., Borbely A.A. Simulation of daytime vigilance by the additive interaction of a homeostatic and a circadian process. Biol. Cybern., 1994, vol. 71, pp. 115–121.
3. Achermann P., Dijk D.J., Brunner D.P., Borbely A.A. A model of human sleep homeostasis based on EEG slow-wave activity: quantitative comparison of data and simulations. Brain Res. Bull., 1993, vol. 31, pp. 97–113.
4. Borbely A.A. A two process model of sleep regulation. Hum Neurobiol., 1982, vol. 1, pp. 195–204.
5. Daan S., Beersma D.G.M., Borbely A.A. Timing of human sleep: Recovery process gated by a circadian pacemaker. Am. J. Physiol., 1984, vol. 246, pp. 161–178.
6. Donskaya O.G., Verevkin E.G., Putilov AA. The first and second principal components of the EEG spectrum as the indicators of sleepiness. Somnologie., 2012, vol. 16 (2), pp. 69–79.
7. Putilov AA. The timing of sleep modelling: circadian modulation of the homeostatic process. Biol. Rhythm. Res., 1995, vol. 26, pp. 1–19.
8. Putilov A.A. Principal component structure of wake-sleep transition: quantitative description in multiple sleep latency tests. Somnologie, 2010, vol. 14. P. 234–243.
9. Putilov A.A. Prospects of using electroencephalographic signatures of the chronoregulatory processes for meaningful, parsimonious and quantitative description of the sleep-wake sub-states. Biol. Rhythm. Res., 2011, vol. 42, pp. 181–207.
10. Putilov A.A. Principal components of electroencephalographic spectrum as markers of opponent processes underlying ultradian sleep cycles. Chronobiol. Int., vol. 28, pp. 287–299.
11. Putilov A.A., Donskaya O.G., Verevkin E.G. Quantification of sleepiness through principal component analysis of the EEG spectrum. Chronobiol. Int., 2012, vol. 29 (4), pp. 509–522.
12. Putilov A.A., Donskaya O.G., Verevkin E.G., Putilov D.A. Associations of waking EEG structure with chronotype and trototype of 130 sleep deprived individuals. Biol. Rhythm. Res., 2010, vol. 41 (2), pp. 113–136.
13. Putilov AA, Donskaya OG, Verevkin EG, Shtark M.B. Structuring the inter-individual variation in waking EEG can help to discriminate between the objective markers of sleep debt and sleep pressure. Somnologi, 2009, vol. 13 (2), pp. 72–88.
14. Rechtschaffen A. and Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. UCLA Brain Information Service/Brain Research Institute, Los Angeles. 1968. 65 p.
Review
For citations:
Putilov A.A., Verevkin Ye.G. A GENERAL MODEL FOR UNIFICATION OF THE THREE PROCESSES OF SLEEP-WAKE REGULATION. Bulletin of Siberian Medicine. 2013;12(2):266-274. (In Russ.) https://doi.org/10.20538/1682-0363-2013-2-266-274
Views:
869
Email this article 