CLIPPERS. Three clinical cases and review
L. N. Prakhova,
A. S. Parfyonova,
Zh. I. Savintseva,
A. G. Ilves,
E. V. Bubnova,
V. S. Krasnov,
A. M. Tarasova,
N. A. Totolyan https://doi.org/10.20538/1682-0363-2019-4-256-265
Abstract
CLIPPERS (Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids) is a rare inflammatory disease of the central nervous system, during which the pons of the brain is damaged. This disease was described for the first time in 2010 by S.J. Pittock et.al. At present, there have been around 50 described cases of the disease. Up to the present moment, there are difficulties diagnosing this disease. In the article, a literature review and three clinical cases are presented. Furthermore, the necessity of further research is shown for improving the accuracy and specificity of the diagnostic criteria, as well as for defining biomarkers and developing algorithms of effective therapy.
About the Authors
L. N. Prakhova
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Head of the Neurorehabilitation Laboratory,
9, Akademika Pavlova Str., St. Petersburg, 197376
A. S. Parfyonova
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
Resident, Department of Neurology,
9, Akademika Pavlova Str., St. Petersburg, 197376
Zh. I. Savintseva
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
PhD, Rentgenologist, Radiology Department,
9, Akademika Pavlova Str., St. Petersburg, 197376
A. G. Ilves
N.P. Bechtereva Institute of the Human Brain of the Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
PhD, Senior Researcher, Neuroimmunology Laboratory,
9, Akademika Pavlova Str., St. Petersburg, 197376
E. V. Bubnova
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor,
6/8, Lva Tolstogo Str., St. Petersburg, 197022
V. S. Krasnov
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Neurology,
6/8, Lva Tolstogo Str., St. Petersburg, 197022
A. M. Tarasova
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
Neurologist,
6/8, Lva Tolstogo Str., St. Petersburg, 197022
N. A. Totolyan
Academician I.P. Pavlov First St. Petersburg State Medical University
Russian Federation
Russian Federation
DM, Professor, Department of Neurology,
6/8, Lva Tolstogo Str., St. Petersburg, 197022
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Review
For citations:
Prakhova L.N., Parfyonova A.S., Savintseva Zh.I., Ilves A.G., Bubnova E.V., Krasnov V.S., Tarasova A.M., Totolyan N.A. CLIPPERS. Three clinical cases and review. Bulletin of Siberian Medicine. 2019;18(4):256-265. (In Russ.) https://doi.org/10.20538/1682-0363-2019-4-256-265
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