NATRIURETIC PEPTIDE AND HIS PROGENITORS AS PREDICTORS OF PROGRESSIVE POSTOPERATIVE LEFT VENTRICLE REMODELING IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY
https://doi.org/10.20538/1682-0363-2013-6-23-30
Abstract
The work is devoted to the study of atrial natriuretic peptide (ANP) and its precursors as one of possible predictors of left ventricular repeated remodeling in patients with ischemic cardiomyopathy (ICMP) in the follow-up (postoperative period). Objects of the study are venous blood and intraoperative samples of right atrial auricle. Precursors of NUP were identified in blood serum by the immuno-fluorescence test. Ultrathin slices of auricle biopsy samples were examined with electronmicroscopy with the use of image processing ImageJ software (program). The concentration of NUP precursors in blood plasma and relation of minimal diameter of secretory granules to maximal one in right auricle cardiomyocytes reflect pathological processes taking place in the myocardium of patients with ICMP. Ratio of minimal and maximal diameters of secretory granules is a predictor of chronic heart failure progressing.
About the Authors
S. S. Gutor
Siberian State Medical University, Tomsk
Russian Federation
Gutor Sergey S.
Russian Federation
Gutor Sergey S.
V. A. Kazakov
Siberian State Medical University, Tomsk;
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Kazakov Vitaliy A.
Russian Federation
Kazakov Vitaliy A.
I. V. Suhodolo
Siberian State Medical University, Tomsk
Russian Federation
Suhodolo Irina V.
Russian Federation
Suhodolo Irina V.
V. M. Shipulin
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Shipulin Vladimir M.
Russian Federation
Shipulin Vladimir M.
V. Ye. Babokin
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Babokin Vadim Ye.
Russian Federation
Babokin Vadim Ye.
O. N. Ogurkova
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Ogurkova Oksana N.
Russian Federation
Ogurkova Oksana N.
S. L. Andreyev
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Andreyev Sergey L.
Russian Federation
Andreyev Sergey L.
A. V. Safonova
Siberian State Medical University, Tomsk
Russian Federation
Safonova Alena V.
Russian Federation
Safonova Alena V.
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Review
For citations:
Gutor S.S., Kazakov V.A., Suhodolo I.V., Shipulin V.M., Babokin V.Ye., Ogurkova O.N., Andreyev S.L., Safonova A.V. NATRIURETIC PEPTIDE AND HIS PROGENITORS AS PREDICTORS OF PROGRESSIVE POSTOPERATIVE LEFT VENTRICLE REMODELING IN PATIENTS WITH ISCHEMIC CARDIOMYOPATHY. Bulletin of Siberian Medicine. 2013;12(6):23-30. (In Russ.) https://doi.org/10.20538/1682-0363-2013-6-23-30
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