ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY
https://doi.org/10.20538/1682-0363-2013-6-43-47
Abstract
The retrospective study was designed to identify association of premature rupture of the fetal membranes (PROM) with carrying polymorphisms in genes encoding folate metabolism and hemostasis in 717 women. More than one hundred potential predictors were analyzed including carriage of thrombogenic genes polymorphisms and genes encoding folate metabolism: FV[Arg506Gln], F II [20210 G/A], MTHFR [Ala222Val], (PAI-I)[-675 5G/4G]. Study revealed that plasminogen activator ingibitor-1 gene polymorphism increases significantly the risk of premature rupture of the fetal membranes in term pregnancy (PROM): heterozygous plasminogen activator ingibitor-1 gene polymorphism is associated with 3.6-fold (95% CI 2.4–5.4; p < 0.001), homozygous plasminogen activator ingibitor-1 gene polymorphism – with 1.7-fold (95% CI 1.1–2.6; p = 0.01) risk rise of PROM.
About the Authors
M. G. Nikolayeva
Altai State Medical University, Barnaul
Russian Federation
Nikolayeva Maria G.
Russian Federation
Nikolayeva Maria G.
G. V. Serdyuk
Hematological Research Center, Barnaul
Russian Federation
Serdyuk Galina V.
Russian Federation
Serdyuk Galina V.
Ye. Ye. Grigoriyeva
Health Care Service and Pharmaceutical Activity Administration, Altai Department, Barnaul
Russian Federation
Grigoriyeva Yelena Ye.
Russian Federation
Grigoriyeva Yelena Ye.
References
1. Bolotskikh V.M. Premature rupture of membranes at term pregnancy: forecasting, pathogenesis, the management of pregnancy and delivery. Author. Dis. Dr. Med. Sci. St. Petersburg, 2013. 38 p. (in Russian).
2. Kozlovskaya I.A. Clinical course features of term labor with preterm rupture of membranes. Author. dis. cand. med. sci. dissertation. Irkutsk, 2009, 28 p. (in Russian).
3. Sidel'nikova V.M., Sukhikh G.T. Miscarriage: A guide for practitioners. Moscow, Med. inform. agency Publ., 2010. 536 p. (in Russian).
4. Aleev I.A. Premature rupture of membranes. Information Letter. Ed. by V.E. Radzinskiy, I.M. Ordiyants. Moscow, Mediabyuro Status Praesens, 2011. 20 p. (in Russian).
5. Daneshmand S.S., Chmait R.H., Moore T.R. et al. Preterm premature rupture of membranes: vascular endothelial growthfactor and its association with histologic chorioamnionitis. Am. J. Obstet. Gynecol., 2002, Nov. 187 (5), рр. 1131 6.
6. Glukhova T.N., Salov I.A., Arzhaeva I.A. Fundamental research, 2011, no. 11, pp. 30–32 (in Russian).
7. Kan N.E., Sannikova M.V., Donnikov A.E., Klimantsev I.V., Amiraslanov E.Yu., Lomova N.A., Kesova M.I., Kostin P.A., Tyutyunnik V.L., Sukhikh G.T. Obstetrics and gynecology, 2013. no. 4, pp. 14–28 (in Russian).
8. Sannikova M.V. Obstetrics and gynecology, 2012. no. 4. pp. 14–28 (in Russian).
9. Tonoyan L.A. Journal of the Russian society of obstetricians-gynecologists, 2009. no.1. pp. 18–22 (in Russian).
10. Joyce E.M., Moore J.J., Sacks M.S. Biomechanics of the fetal membrane prior to mechanical failure: review and implications. Eur. J. Obstet. Gynecol. Reprod. Biol., 2009, 144 (Suppl. 1), S121–7.
11. Palei A.C., Sandrim V.C., Cavalli R.C., Tanus-Santos J.E. Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension. Clin. Biochem., 2008, 41 (10– 11), рр. 875–80.
12. Trukhacheva N.V., Pupyrev N.P. A practical guide to the statistical analysis of experimental data. Barnaul, 2010. 249 p. (in Russian).
Review
For citations:
Nikolayeva M.G., Serdyuk G.V., Grigoriyeva Ye.Ye. ROLE OF GENE POLYMORFISM OF PLASMINOGEN ACTIVATOR INGIBITOR TYPE I AS A RISK FACTOR FOR PREMATURE RUPTURE OF MEMBRANE AT TERM PREGNANCY. Bulletin of Siberian Medicine. 2013;12(6):43-47. (In Russ.) https://doi.org/10.20538/1682-0363-2013-6-43-47
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