MORPHOLOGICAL FEATURES OF LUNG STRUCTURE AND FUNCTIONAL ACTIVITY OF THE AIRWAYS OF GUINEA PIGS AFTER LONG-TERM EXPOSURE WITH NANOSIZED MAGNETITE A
https://doi.org/10.20538/1682-0363-2013-1-7-13
Abstract
The results of study, in which we examined the influence of nanosized magnetite on breath organs histological structure and contractility activity of the airways of guinea pigs by method of mechanography has been presented. In the lungs of experimental animals an inflammatory response developed as a result of long-term inhalation intake of nanosized magnetite. Also the functional status of the airways changed and appeared as changing of amplitude of contractility response under the action of histamine.
About the Authors
Ye. Ye. Abramenko
Siberian State Medical University, Tomsk
Russian Federation
Department of biophysics and functional diagnostics SSMU
Russian Federation
Department of biophysics and functional diagnostics SSMU
A. V. Nosarev
Siberian State Medical University, Tomsk
Russian Federation
Department of biophysics and functional diagnostics SSMU
Russian Federation
Department of biophysics and functional diagnostics SSMU
L. V. Smaglyi
Siberian State Medical University, Tomsk
Russian Federation
Department of biophysics and functional diagnostics SSMU
Russian Federation
Department of biophysics and functional diagnostics SSMU
L. V. Kapilevich
Siberian State Medical University, Tomsk
Russian Federation
Department of biophysics and functional diagnostics SSMU
Russian Federation
Department of biophysics and functional diagnostics SSMU
Ye. Yu. D’yakova
Siberian State Medical University, Tomsk
Russian Federation
Department of biophysics and functional diagnostics SSMU
Russian Federation
Department of biophysics and functional diagnostics SSMU
A. M. Tabayeva
Siberian State Medical University, Tomsk
Russian Federation
Student
Russian Federation
Student
T. A. Kironenko
Siberian State Medical University, Tomsk
Russian Federation
Student
Russian Federation
Student
V. S. Selivanova
Siberian State Medical University, Tomsk
Russian Federation
Student
Russian Federation
Student
References
1. . Antipov S.A., Dambaev G.Ts., Ermakov A.Ye., Kokarev O.V., Svarovskaya L.I., Uymin M.A., Feduschak T.A., Khlusov I.A. Bulletin of new medical technologies, 2009, vol. 16, no. 2, pp. 139–145 (in Russian).
2. Dyakova E.Yu. Contractile properties of bronchial smooth muscle in the airway hyperresponsiveness formation. Dis. kand. med. nauk. 2004. Tomsk. SSMU Publ. 144 p. (in Rus-sian).
3. Kapilevich L.V., Dyakova Ye.Yu., Zaitseva T.N., Petlina Z.R., Ogorodova L.M., Ageyev B.G., Magayeva A.A., Itin V.I., Terekhova O.G., Nosarev A.V. Vestnik Sank-Peterburgskoj gosudarstvennoj medicinskoj akademii im. I.I. Mechnikova, 2009, vol. 30, no. 1. pp. 74–78.
4. Mil'to, I.V., Magaeva A.A., Mal'ceva O.A. Histological con-trol of penetration of nanoparticles into the bloodstream of rats by intraperitoneal solution Fe3O4 nanopowder. St. Petersburg Scientific Conference: Proceedings of the II International Youth Medical Congress. SPb. Publ. 2007. pp. 100–101 (in Russian).
5. Nosarev A.V., Abramenko Ye.Ye., Kapilevich L.V., Vasiliyev V.N., Diyakova Ye.Yu., Tabayeva A.M., Kironenko T.A., Perfiliyeva V.V., Mil’to I.V. Bulletin of Si-berian medicine, 2012, vol. 11, no. 1, pp. 52–59 (in Russian).
6. Fathutdinova L.M., Haliullin T.O., Zaljalov R.R. Medical journal of Kazan, 2009, vol. 90, no. 4, pp. 578–584 (in Rus-sian).
7. Shevcova N.M., Paderov Yu.M., Stepovaya Ye.A. et al. Bul-letin of the Siberian Branch of RAMS, 2005, no. 4 (118), pp. 90–92 (in Russian).
8. Birukov K. Cyclic Stretch, Reactive Oxygen Species, and Vascular Remodeling. Antioxid Redox Signal, 2009, vol. 11, no. 7, рp. 1651–1667.
9. Crosswhite P., Sun Zh. Nitric oxide, oxidative stress and in-flammation in pulmonary arterial hypertension. J. Hypertens, 2010, vol. 28, no. 2, рp. 201–212.
10. Mauban J.R., Wilkinson K., Schach C., Yuan J.X. Histamine-mediated Increases in Cytosolic [Ca2+] Involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am. J. Physiol. Cell. Physiol, 2006, vol. 290, no. 2, рp. C325–C336.
11. Medina C., Santos-Martinez M.J., Radomski A. Corrigan O., Radomski M. Nanoparticles: pharmacological and toxico-logical significance. Br. J. Pharmacol, 2007, no. 50, pp. 552–558.
12. Möller W. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. American Journal of Respiratory and Critical Care Medicine, 2008, vol. 177, no. 3, рp. 426–432.
13. Ray P., Yu H., Fu P. Toxicity and environmental risks of nanomaterials: challenges and future needs. J. Environ Sci. Health. C Environ Carcinog. Ecotoxicol. Rev., 2009, vol. 27, no. 1, рp. 1–35.
14. Sun J., Wang S., Zhao D., Hun FH., Weng L., Liu H. Cyto-toxicity, permeability, and inflammation of metal oxide na-noparticles in human cardiac microvascular endothelial cells. Cell Biology and Toxicology, 2011, vol. 27, no. 5, р. 333–342.
15. Sun Y., Zhang Y., Sundell J. Dampness in dorm rooms and its associations with allergy and airways infections among college students in China: a cross-sectional study. Indoor Air, 2009, vol. 19, no. 4, pp. 348–350.
16. Yan-Ping D. ClC-3 chloride channel is upregulated by hy-pertrophy and inflammation in rat and canine pulmonary ar-tery. Br. J. Pharmacol, 2005, vol. 145, no. 1, рp. 5–14.
Review
For citations:
Abramenko Ye.Ye., Nosarev A.V., Smaglyi L.V., Kapilevich L.V., D’yakova Ye.Yu., Tabayeva A.M., Kironenko T.A., Selivanova V.S. MORPHOLOGICAL FEATURES OF LUNG STRUCTURE AND FUNCTIONAL ACTIVITY OF THE AIRWAYS OF GUINEA PIGS AFTER LONG-TERM EXPOSURE WITH NANOSIZED MAGNETITE A. Bulletin of Siberian Medicine. 2013;12(1):7-13. (In Russ.) https://doi.org/10.20538/1682-0363-2013-1-7-13
Views:
730
Email this article 