Reaction of neurons of internal layers of the retina to combined influence of ionizing radiation and light
https://doi.org/10.20538/1682-0363-2006-2-96-100
Abstract
The purpose of the presented work was the establishment of a character of modifying influence of ionizing radiation on damages of neurons of internal nuclear and ganglionic layers of a retina caused by light. The investigation revealed that changes of neurons of the internal nuclear and ganglionic layers after X-ray, light (200 lk, the 1st, 2nd, 7th, 14th, 30th days) and combined influence have similar nature, but differ in a degree of expression and manifest by reactive and destructive changes of organelles. Associated neurons showed relative resistance to investigated influences in comparison with multi-polar neurons of ganglionic layer. Combined ionizing radiation and light cause substantial growth of number of hyper-chrome and picnotic multi-polar neurons of ganglionic layer of a retina. Synergic effect is mostly expressed on 7-th-14-th day of the experiment and results in progressing growth of the number of hyper chrome multi-polar neurons.
About the Authors
A. V. Potapov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. V. Svetlik
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Ахмадеев А.В., Калимулина Л.Б., Минибаева З.Р. Нейросекреторные клетки миндалевидного комплекса мозга // Бюл. эксперим. биологии. 1999. Т. 119. № 4. С. 368—374.
2. Витвицкая Л.В. Сравнительный анализ функций генома в клетках мозга при формировании адаптивного поведения у животного разного уровня онтои филогенеза: Автореф. дис.. д-ра мед. наук. М., 1991. 29 с.
3. Голубовский М.Д. Организация генотипа и формирование наследственной изменчивости эукариотов // Успехи соврем. биологии. 1985. Т. 100. № 3. С. 323—331.
4. Калимулина Л.В. Вопрос о «темных» и «светлых» клетках // Морфология. 2002. Т. 122. № 4. C. 75—80.
5. Goide R., Ueda T.N., Dawson W.W. et al. Retinal hazard from blue light emitting diode // Nippon. Ganka. Gakkai. Zasshi. 2001. V. 105. № 10. Р. 687—695.
6. Kleinmann G., Hoffman P., Schechtman E., Pollack A. Microscope-induced retinal phototoxicity in cataract surgery of short duration // Ophthalmology. 2002. V. 109. № 2. Р. 334—338.
7. Kohnen S. Light-induced damage of the retina through slit-lamp photography // Graefes Arch. Clin. Exp. Ophthalmol. 2000. V. 238. № 12. Р. 956—959.
8. Li F., Cao W., Anderson R.E. Alleviation of constant-light-induced photoreceptor degeneration by adaptation of adult albino rat to bright cyclic light // Invest. Ophthalmol. Vis. Sci. 2003. V. 44. № 11. Р. 4968—4975.
9. Masuda K., Watanabe I. Short wavelength light-induced retinal damage in rats // Jpn. J. Ophthalmol. 2000. V. 44. № 6. P. 615—619.
10. Michael R., Wegener A. Estimation of safe exposure time from an ophthalmic operating microscope with regard to ultraviolet radiation and blue-light hazards to the eye // J. Opt. Soc. Am. A. Opt. Image Sci. Vis. 2004. V. 21. № 8. Р. 1388—1392.
11. Walsh N., Valter K., Stone J. Cellular and subcellular patterns of expression of bFGF and CNTF in the normal and light stressed adult rat retina. // Exp. Eye. Res. 2001 V. 72. № 5. Р. 495—501.
Review
For citations:
Potapov A.V., Svetlik M.V. Reaction of neurons of internal layers of the retina to combined influence of ionizing radiation and light. Bulletin of Siberian Medicine. 2006;5(2):96-100. (In Russ.) https://doi.org/10.20538/1682-0363-2006-2-96-100
Views:
359
Email this article 