Reaction of visual nerve to combined influence of ionizing of radiation and bright light
https://doi.org/10.20538/1682-0363-2006-2-133-136
Abstract
Aimed at revealing the character of modifying influence of ionizing radiation on damages of visual nerve caused by bright light, three series of the experiment were performed. Rats of the first group (n = 10) were subjected to uniform irradiation by LB-40 luminescent lamps (3500 lk, 48 hours). Rats of the second group (n = 20) were subjected to unitary total X-ray radiation in a dozes of 10 and 15 Gr, and rats of the third group ( n = 20) were subjected to combined total influence of x-ray radiation and light of abovementioned parameters with an interval of one hour. The investigation showed that changes in visual nerve after ionizing (10, 15 Gr), light and combined influences are manifested in destruction of organelles, neuro-tubes and neuro-filamentes in axial cylinders and in demyelinizing changes. Quantitative analysis showed that reactions of visual nerve caused by the influence of ionizing radiation are resulted mainly in demyelinization of eye coat and are doze dependent. Combination of investigated factors causes synergic effect which is characterized by increased number of nervous conductors with degenerative changes of axial cylinders and mielinic coats.
References
1. Василенко И.Я. Радиобиологические проблемы малых доз радиации // Воен.-мед. журн. 1993. № 4. С. 28—32.
2. Котелянская К.Е., Обуховский Г.А. Ангиопатии органа зрения у жителей радиационно пораженных территорий Ровенской области // Офтальмол. журн. 2000. №. 5. С. 43—45.
3. Логвинов С.В. Радиация и зрительный анализатор: нейроморфологические аспекты. Томск: Изд-во Том. ун-та, 1998. 138 с.
4. Dawson D.G., Edelhauser H.F., Grossniklaus H.E. Long-term histopathologic findings in human corneal wounds after refractive surgical procedures // Am. J. Ophthalmol. 2005. V. 139. № 1. Р. 168—178.
5. Demirchoglian G.G. On the effect of ionizing radiation upon the retina in man and animals // Annu. Rev. Biophys. Biomol. Struct. 2002. V. 31. P. 443—484.
6. Huaqing G., Tsugio A. Optic nerve changes in manganese-deficient rats // Experim. Eye Research. 1999. V. 68. № 3. P. 313—320.
7. Meyer-Rochow V.B. Risks, especially for the eye, emanating from the rise of solar UV-radiation in the Arctic and Antarctic regions // Int. J. Circumpolar Health. 2000. V. 59. № 1. P. 38—51.
8. Michael R., Wegener A. Estimation of safe exposure time from an ophthalmic operating microscope with regard to ultraviolet radiation and blue-light hazards to the eye // J. Opt. Soc. Am. A. Opt. Image Sci. Vis. 2004. V. 21. № 8. Р. 1388—1392.
9. Rodriguez-Sains R. Looking at the sun: A danger to the eyes // Prim. Care and Cancer. 2001. V. 21. № 5. P. 34—36.
10. Grozdanic S.D., Kwon Y.H., Sakaguchi D.S. et al. Functional evaluation of retina and optic nerve in the rat model of chronic ocular hypertension // Experim. Eye Research. 2004. V. 79. № 1. P. 75—83.
11. Uhlig C.E., Gerding H. Estimation of safe exposure time from an ophthalmic operating microscope with regard to ultraviolet radiation and blue-light hazards to the eye // J. Opt. Soc. Am. A. Op.t Image. Sci Vis. 2004. V. 21. № 8. Р. 1388—1392.
12. Yoshinori Dake, Tsugio Amemiya. Electron microscopic study of the optic nerve in copper deficient rats // Experimental Eye Research. 1991. V. 52. № 3. P. 277—281.
Review
For citations:
Potapov A.V. Reaction of visual nerve to combined influence of ionizing of radiation and bright light. Bulletin of Siberian Medicine. 2006;5(2):133-136. (In Russ.) https://doi.org/10.20538/1682-0363-2006-2-133-136
Views:
403
Email this article 