THE DYNAMICS OF IN VITRO DEGRADATION OF NON-WOVEN POLYLACTIDE MATRICES IN MODEL BIOLOGICAL LIQUID
https://doi.org/10.20538/1682-0363-2013-6-73-81
Abstract
The weekly in vitro degradation of fibrous-porous non-woven polylactide scaffolds made by aerodynamic formation in a turbulent gas flow has been studied with 37 °С in model RPMI-1640 medium imitated body fluid of organism. Lactate monomers released into solution exponentially and reached slowly a maximum value the end of the observation (5th week of dissolution). At the same time, reducing the concentrations of calcium and inorganic phosphorus ions in solutions contacted with tested samples (10×10×1 mm2) testified about chemical elements adsorption on artificial material. Ions exchange with biological fluids may be a basis of regulated bioactivity of fibrous-porous non-woven biodegradable material in application to intercellular matrix bioengineering for regenerative medicine
About the Authors
I. A. Khlusov
Siberian State Medical University, Tomsk;
National Research Tomsk Polytechnic University, Tomsk
Russian Federation
Khlusov Igor A.
Russian Federation
Khlusov Igor A.
K. V. Zaitsev
Tomsk Research Institute of Balneology and Physiotherapy, FMBA of Russia, Tomsk
Russian Federation
Zaitsev Konstantin V.
Russian Federation
Zaitsev Konstantin V.
O. B. Zhukova
Tomsk Research Institute of Balneology and Physiotherapy, FMBA of Russia, Tomsk
Russian Federation
Zhukova Oksana B.
Russian Federation
Zhukova Oksana B.
A. A. Gostyukhina
Tomsk Research Institute of Balneology and Physiotherapy, FMBA of Russia, Tomsk
Russian Federation
Gostyukhina Alyena A.
Russian Federation
Gostyukhina Alyena A.
N. G. Abdulkina
Tomsk Research Institute of Balneology and Physiotherapy, FMBA of Russia, Tomsk
Russian Federation
Abdulkina Natalya G.
Russian Federation
Abdulkina Natalya G.
A. A. Zaitsev
Siberian State Medical University, Tomsk;
Tomsk Research Institute of Balneology and Physiotherapy, FMBA of Russia, Tomsk
Russian Federation
Zaitsev Aleksey A.
Russian Federation
Zaitsev Aleksey A.
I. V. Kulagina
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Kulagina Irina V.
Russian Federation
Kulagina Irina V.
S. I. Tverdokhlebov
National Research Tomsk Polytechnic University, Tomsk
Russian Federation
Tverdokhlebov Sergey I.
Russian Federation
Tverdokhlebov Sergey I.
E. N. Bolbasov
National Research Tomsk Polytechnic University, Tomsk
Russian Federation
Bolbasov Eugeny N.
Russian Federation
Bolbasov Eugeny N.
K. S. Stankevich
National Research Tomsk Polytechnic University, Tomsk
Russian Federation
Stankevich Xenia S.
Russian Federation
Stankevich Xenia S.
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Review
For citations:
Khlusov I.A., Zaitsev K.V., Zhukova O.B., Gostyukhina A.A., Abdulkina N.G., Zaitsev A.A., Kulagina I.V., Tverdokhlebov S.I., Bolbasov E.N., Stankevich K.S. THE DYNAMICS OF IN VITRO DEGRADATION OF NON-WOVEN POLYLACTIDE MATRICES IN MODEL BIOLOGICAL LIQUID. Bulletin of Siberian Medicine. 2013;12(6):73-81. (In Russ.) https://doi.org/10.20538/1682-0363-2013-6-73-81
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