Haematoretinal barrier reaction on combined exposure of ionizing radiationand bright light
https://doi.org/10.20538/1682-0363-2007-2-42-46
Abstract
The aim of this work was to determine character of modifying radiation influence on damages of haematoretinal barrier components which is caused by light. The study showed that preliminary total x-ray radiation (5 Gy) increases lightning damages (3 500 lx, on the 1-st, 2-nd, 7-th, 14-th, 30-th days) of haematoretinal barrier which manifest by decreased specific square of chorioideas open capillaries, by haemodynamic disorders, reactive and destructive changes of pigmental epithelium. Damages of haematoretinal barrier is of focal character and are mostly l expressed on the areas of retina with massive destruction of neurosensory cells.
About the Authors
A. V. PotapovRussian Federation
Ye. Yu. Varakuta
Russian Federation
S. V. Logvinov
Russian Federation
A. A. Zhdankina
Russian Federation
Ye. P. Mikhoulya
Russian Federation
Ye. Yu. Anikina
Russian Federation
References
1. Амиров А.Н. Гигиенические и офтальмологические аспекты коррекции профессионально значимых зрительных нарушений у пользователей видеодисплейных терминалов: Автореф. дис. ... канд. мед. наук. Казань, 2001. 27 с.
2. Антипов В.В., Федоров В.П., Ушаков И.Б., Давыдов Б.И. Проблемы космической биологии. Л.: Наука, 1989. Т. 66. 328 с.
3. Бредбери М. Концепция гематоэнцефалического барьера. М.: Медицина, 1983. 480 с.
4. Василенко И.Я. Радиобиологические проблемы малых доз радиации // Воен.-мед. журн. 1993. № 4. С. 28-32.
5. Гусова Б.А., Асланукова Л.А. Повышение устойчивости зрительной системы у пользователей зрительных видеотерминалов // Материалы 55-й региональной конференции по фармации, фармакологии и подготовке кадров. Пятигорск, 2000. С. 183.
6. Котелянская К.Е., Обуховский Г.А. Ангиопатии органа зрения у жителей радиационно пораженных территорий Ровенской области // Офтальм. журн. 2000. № 5. С. 43-45.
7. Aydemir O., Celebi S., Yilmaz T. et al. Protective Effects of Vitamin E Forms (Alpha-tocopherol, Gamma-tocopherol and d-alpha-tocopherol Polyethylene Glycol 1000 Succinate) on Retinal Edema During Ischemia-reperfusion Injury in the Guinea Pig Retina // Int. Ophthalmol. 2004. V. 25. № 5-6. P. 283-289.
8. Cahill G.M., Besharse J.C. Light-sensitive melatonin synthesis by Xenopus photoreceptors after destruction of the inner retina // Vis. Neurosci. 1992. V. 8. № 5. P. 487-490.
9. Demirchoglian G.G. On the effect of ionizing radiation upon the retina in man and animals // Annu. Rev. Biophys. Biomol. Struct. 2002. V. 31. P. 443-484.
10. Kozaki J., Takeuchi M., Takehashi K. et al. Light-induced retinal damage in pigmented rabbit-2. Effect of alpha-tocopherol // Jpn. J. Ophthalmol. 1992. V. 36. № 3. P. 315-322.
11. Organisciak D.T., Li M., Darrow R.M., Farber D.B. Photoreceptor cell damage by light in young Royal College of Surgeons rats // Curr. Eye Res. 1999. № 19. Р. 188-196.
12. Peyman G.A., Kazi A.A., Unal M. et al. Problems with and pitfalls of photodynamic therapy // Ophthalmology. 2000. V. 107. № 1. Р. 29 -35.
13. Wenzel A., Reme C.E., Williams T.P. et al. The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration // J. Neurosci. 2001. V. 21. № 1. Р. 53-58.
14. Winkler B.S., Boulton M.E., Gottsch J.D., Sternberg P. Oxidative damage and age-related macular degeneration // Molecular Vision. 1999. № 5. Р. 32.
Review
For citations:
Potapov A.V., Varakuta Ye.Yu., Logvinov S.V., Zhdankina A.A., Mikhoulya Ye.P., Anikina Ye.Yu. Haematoretinal barrier reaction on combined exposure of ionizing radiationand bright light. Bulletin of Siberian Medicine. 2007;6(2):42-46. (In Russ.) https://doi.org/10.20538/1682-0363-2007-2-42-46