Polymorphism of a gene IL12B in patients with multiple sclerosis and healthy persons

Abstract

We examined of 62 patients with various types of multiple sclerosis current, which middle age has made (31,8 ± 1,2) years. It has been lead genotyping by means of PCR by a polymorphic variant 1188A/С gene IL12B in 3`-not broadcast area and has been found out not only higher frequency of alleles C of a gene IL12B in comparison with healthy persons, but also the association with more active of MS current is revealed. At the analysis of immunological parameters of patients depending on a genotype IL12B, it has been found at carriers alleles C the tendency to reduction absolute maintenance of mature T-lymphocytes and increase CD25⁺ and CD95⁺.