The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease
https://doi.org/10.20538/1682-0363-2004-2-29-34
Abstract
Association of –308G/A-polymorphism of α-tumor necrosis factor (TNF) gene with the development of chronic obstructive pulmonary disease has been investigated in two populations of Tomsk city (Siberian Tatars and Russians). As a result, it has not been marked any genotype distribution deviation of expected in patient groups as well as in control groups at Hardy-Vainberg equilibrium. Statistically significant difference in allele distribution rate at patients with COPD and in control groups has not been found (p > 0,5) including ethnic groups (Russians and Tatars). Differences in genotype distribution at patients and control group have been found for Tatars due to heterosive carrier (AG) prevalence at patients (p < 0,05). The obtained data allow to conclude the presence of association of –308G/A-polymorphism of TNF gene with the COPD development at Siberian Tatars.
About the Authors
G. N. Seitova
Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
Ye. B. Bukreeva
Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
S. V. Buykin
Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
O. Yu. Bychkova
Research Institute of Medical Genetics
Russian Federation
Russian Federation
Tomsk
Ye. A. Dementyeva
Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
S. V. Nesterovich
Siberian State Medical University
Russian Federation
Russian Federation
Tomsk
V. P. Puzyryov
Siberian State Medical University; Research Institute of Medical Genetics
Russian Federation
Russian Federation
Tomsk
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Review
For citations:
Seitova G.N., Bukreeva Ye.B., Buykin S.V., Bychkova O.Yu., Dementyeva Ye.A., Nesterovich S.V., Puzyryov V.P. The role of polymorphism in TNF gene promotive area in the development of chronic obstructive pulmonary disease. Bulletin of Siberian Medicine. 2004;3(2):29-34. (In Russ.) https://doi.org/10.20538/1682-0363-2004-2-29-34
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