Exogenic and endogenic factors in chronic obstructive pulmonary disease forming
https://doi.org/10.20538/1682-0363-2003-1-75-77
Abstract
To determine the role of exogenic and endogenic factors in chronic obstructive pulmonary disease (COPD) forming 100 patients (50 patients are control group) were examined by means of clinical and genealogical researches, including family tree composition with analisis of 3—4 generations, genotyping on the most wide-spread α1-proteinase inhibitor (α1-PI) gene alleles (M, S, Z), definition of the α1-PI level in the serum. The role of exogenic factors (smoking, pollutants) have been confirmed in COPD forming, while primery α1-PI deficiency have been revealed only in 6% COPD patients. Therefore, further investigations of other genetic alleles in COPD patients are necessary.
About the Authors
E. B. Bukreeva
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
S. A. Bogushevich
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
E. A. Dementieva
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
G. E. Chernogoryuk
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
S. V. Nesterovich
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
G. N. Seitova
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
S. V. Buikin
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscowski Trakt, Tomsk, 634050
References
1. Хронические обструктивные болезни легких. Федеральная программа. М., 1999. 40 с.
2. American Thoracic Society. Standarts for the diagnosis and care of patients with chronic obstructive pulmonary disease // AM. J. Respir. Crit. Care Med. 1995. V. 152. P. 77—120.
3. Anto J.M., Vermeire P., Sunyer J. Chronic obstructive pulmonary disease // Eur. Respir. Monograph: Respir. Epidemiology in Europe. 2000. V. 5. № 15. P. 1–22.
4. Barnes P.J. Epidemiology of chronic obstructive pulmonary disease. 1997.
5. Barnes P.J. New therapies for chronic obstructive pulmonary disease // Thorax. 1998. V. 53. P. 137—147.
6. Braun A., Meyer P., Cleve H., Roscher A. Rapid and simples diagnosis of the two common α1-proteinase inhibitor deficiency alleles Pi Z and Pi S by DNA analysis // Eur. J. Clin. Chem. Clin. Biochem. 1996. V. 34. P. 761—764.
7. Dahl M., Tibjaerg-Hansen A., Lange P., Vestbo J., et al. Change in lung function and morbidity for chronic obstructive pulmonary disease in α1-antitripsin MZ heterozigotes: a longitudinal study of the general population // Ann. Inter. Med. 2002. V. 136. № 4. P. 270—279.
8. Lomas D.A. Advances in genetics: alpha1 – antitripsin deficiency // Eur. Respir. Rev. 2000. V. 10. № 74. P. 358—364.
9. Meijer G.G., Koppelman G.H., Postma D.S. Genetic factors / G.G. Meijer // Eur. Respir. Monograph: Respir. Epidemiology in Europe. 2000. V. 5. № 15. P. 247—271.
10. Peto R., Lopez A.D., Boreham J., Thum M., et al. Mortality from tobacco in developed countries: indirect estimation from national vital statistics // Lancet. 1992. V. 339. P. 1268—1278.
11. Rijcken B., Schouten J., Weiss S.T. et al. Long term variability of bronchial responsiventss to histamine in a random sample of adults // Am. Rev. Respir. Dis. 1993. V.148. P. 944—949.
12. Sandford A.J., Weir T.D., Pare P.D. Genetic risk factors for chronic obstrucnive pulmonary disease // Eur. Respir. J. 1997. V. 10. P. 1380—1391.
Review
For citations:
Bukreeva E.B., Bogushevich S.A., Dementieva E.A., Chernogoryuk G.E., Nesterovich S.V., Seitova G.N., Buikin S.V. Exogenic and endogenic factors in chronic obstructive pulmonary disease forming. Bulletin of Siberian Medicine. 2003;2(1):75-77. (In Russ.) https://doi.org/10.20538/1682-0363-2003-1-75-77
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