Peculiarities of polymorphism of Helicobacter pylori virulence genes and IL-1 genes in peptic ulcer of stomach and duodenum, associated with Helicobacter pylori
https://doi.org/10.20538/1682-0363-2005-0-31-35
Abstract
The prevalence of H.pylori virulence genes (iceA, cagA, babA2, vacA) as well as the distribution of the IL-1 genes was studied in patients with H.pylori-associated gastric and duodenal ulcer disease. VacA s1/m2 iceA1 cagA+ и vacA s1/m2 iceA1 cagA+ babA2 genotypes of H. pylori were shown to be prevalent in the clinic isolates. Four patients were found to be infected with Ureaplasma urealyticum. The combination of the IL‑1B ‑511*Т / IL‑1B +3954*C / IL-1RN*2 alleles was shown to be prevalent among the patients with gastric and duodenal ulcer disease. The correlation between the H. pylori genotypes, the IL-1 genes and the peculiarities of ulcer disease was not found.
About the Authors
O. A. Tchernova
Казанский институт биохимии и биофизики КазНЦ РАН
Russian Federation
Russian Federation
E. R. Nasybullina
Казанский институт биохимии и биофизики КазНЦ РАН
Russian Federation
Russian Federation
O. V. Gorshkov
Казанский институт биохимии и биофизики КазНЦ РАН
Russian Federation
Russian Federation
G. F. Shaimardanova
Казанский институт биохимии и биофизики КазНЦ РАН
Russian Federation
Russian Federation
V. M. Tchernov
Казанский институт биохимии и биофизики КазНЦ РАН
Russian Federation
Russian Federation
R. A. Abdulkhakov
Казанский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Tchernova O.A., Nasybullina E.R., Gorshkov O.V., Shaimardanova G.F., Tchernov V.M., Abdulkhakov R.A. Peculiarities of polymorphism of Helicobacter pylori virulence genes and IL-1 genes in peptic ulcer of stomach and duodenum, associated with Helicobacter pylori. Bulletin of Siberian Medicine. 2005;4:31-35. (In Russ.) https://doi.org/10.20538/1682-0363-2005-0-31-35
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