LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN
https://doi.org/10.20538/1682-0363-2013-1-61-68
Abstract
Local and system influence the Repleri gel implants on the base of hyaluronic acid used to correct age-related changes in skin has been studied. Human stromal stem cells with CD44 membrane receptor to hyaluronic acid migrates in vitro into gel structure and maturates morphologically in fibroblast-like forms stained positively with acid phosphatase. Repleri gels implantation in the group of women with local and system age-related changes in homeostasis has positive local effect connected with full deletion of nasolabial fold in facial skin. Repleri gels injection has been decreasing during
1 year the system indices of real biological age as compared with chronological (passport) one. Lipoproteins and aspartate aminotransferase concentrations diminished statistically in women blood. An effect revealed may be considered as potential way of anti-age therapy of not only skin but parenchymal organs. At the same time, a long-term control of homeostasis distant indices in women with serious changes in parenchymal organs is necessary after local Repleri gels injection because of organism’s hormonal reactions.
1 year the system indices of real biological age as compared with chronological (passport) one. Lipoproteins and aspartate aminotransferase concentrations diminished statistically in women blood. An effect revealed may be considered as potential way of anti-age therapy of not only skin but parenchymal organs. At the same time, a long-term control of homeostasis distant indices in women with serious changes in parenchymal organs is necessary after local Repleri gels injection because of organism’s hormonal reactions.
Keywords
stromal stem cells,
in vitro,
acid phosphatase,
women,
nasolabial fold,
blood,
biochemis-try,
hormones
About the Authors
I. A. Khlusov
Scientific Educational Center “Biocompatible Materials and Bioengineering”, Chair of Morphology and General Pathology of Siberian State Medical University;
Bioconstructor-S Ltd., Tomsk
Russian Federation
Khlusov Igor A.
Russian Federation
Khlusov Igor A.
V. A. Igumnov
Siberian Polyclinics Ltd.
Russian Federation
Igumnov Vitali A.
Russian Federation
Igumnov Vitali A.
D. I. Choukhnova
Siberian Polyclinics Ltd.
Russian Federation
Choukhnova Diana L.
Russian Federation
Choukhnova Diana L.
O. L. Mytasova
Siberian Polyclinics Ltd.
Russian Federation
Mytasova Olga L.
Russian Federation
Mytasova Olga L.
K. V. Zaitsev
Laboratory of Study of Mechanisms of Physical factors Action, Tomsk SRI of Balneology and Physiotherapy, Tomsk
Russian Federation
Zaitsev Konstantin V.
Russian Federation
Zaitsev Konstantin V.
N. G. Abdulkina
Tomsk SRI of Balneology and Physiotherapy, Tomsk
Russian Federation
Abdulkina Natalya G.
Russian Federation
Abdulkina Natalya G.
A. A. Zaitsev
Tomsk SRI of Balneology and Physiotherapy, Tomsk
Russian Federation
Zaitsev Aleksey A.
Russian Federation
Zaitsev Aleksey A.
L. Yu. Kolesova
NovoNexus Ltd., Moscow
Russian Federation
Kolesova Liah Yu.
Russian Federation
Kolesova Liah Yu.
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For citations:
Khlusov I.A., Igumnov V.A., Choukhnova D.I., Mytasova O.L., Zaitsev K.V., Abdulkina N.G., Zaitsev A.A., Kolesova L.Yu. LOCAL AND SYSTEM EFFECTS OF HYALURONIC ACID IMPLANTS IN CONDITIONS OF CORRECTIONS OF AGE-RELATED CHANGES IN SKIN. Bulletin of Siberian Medicine. 2013;12(1):61-68. (In Russ.) https://doi.org/10.20538/1682-0363-2013-1-61-68
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