Diagnostic markers of local allergic rhinitis
https://doi.org/10.20538/1682-0363-2021-3-161-167
Abstract
Local allergic rhinitis is a new atopic disease recognized in modern allergy and rhinology. Its clinical symptoms are currently well described and compared with conventional allergic rhinitis, however, diagnostic and therapeutic protocols, including antigen-specific immunotherapy (ASIT), should be specified.
Therefore, local allergic rhinitis often remains underdiagnosed and by mistake is referred to non-allergic rhinitis. Yet, the pathogenesis and mechanisms of allergen tolerance breakdown in this endotype of allergic rhinitis remain understudied. Researchers continue to study the network of tolerogenic cells and biomolecules, such as regulatory T cells, tolerogenic dendritic cells, interleukin (IL)-10, IL-35, transforming growth factor-β (TGF-b), vegetative innervation of the nose, and neurotransmitters.
The review focuses on diagnostic markers of local allergic rhinitis.
About the Authors
A. V. Klimov
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscow Trakt, Tomsk, 634050, Russian Federation
V. V. Klimov
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscow Trakt, Tomsk, 634050, Russian Federation
S. A. Koval
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscow Trakt, Tomsk, 634050, Russian Federation
V. S. Sviridova
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscow Trakt, Tomsk, 634050, Russian Federation
N. S. Koshkarova
Siberian State Medical University
Russian Federation
Russian Federation
2, Moscow Trakt, Tomsk, 634050, Russian Federation
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Review
For citations:
Klimov A.V., Klimov V.V., Koval S.A., Sviridova V.S., Koshkarova N.S. Diagnostic markers of local allergic rhinitis. Bulletin of Siberian Medicine. 2021;20(3):161-167. https://doi.org/10.20538/1682-0363-2021-3-161-167
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