Polymorphism rs3088232 in the BRDT gene is associated with idiopathic male infertility in the West Siberian Region of Russia
https://doi.org/10.20538/1682-0363-2012-3-18-21
Abstract
Allelic variants of genes involved in spermatogenesis can contribute to the genetic predisposition to idiopathic male infertility. In the present study we investigated the association of polymorphism rs3088232 in the BRDT gene with the risk of this pathology on the sample of 105 infertile patients and 230 healthy controls. We revealed the association of allele G (OR = 1.80; CI 1.16—2.80; p = 0.008) and genotype GG (OR = 6.47; CI 1.23—34.15; p = 0.01) with idiopathic male infertility.
About the Authors
A. S. Wainer
Институт химической биологии и фундаментальной медицины СО РАН, Новосибирский государственный университет, г. Новосибирск
Russian Federation
Russian Federation
V. M. Nagaitsev
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation
Russian Federation
O. V. Korolkova
Институт химической биологии и фундаментальной медицины СО РАН, г. Новосибирск
Russian Federation
Russian Federation
V. V. Vostrikov
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation
Russian Federation
L. V. Osadchuk
Институт цитологии и генетики СО РАН, г. Новосибирск
Russian Federation
Russian Federation
Ye. V. Pechkovsky
Институт химической биологии и фундаментальной медицины СО РАН, г. Новосибирск
Russian Federation
Russian Federation
I. S. Malinovskaya
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
M. L. Filipenko
Институт химической биологии и фундаментальной медицины СО РАН, г. Новосибирск
Russian Federation
Russian Federation
References
1. Aston K.I., Carrell D.T. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and
2. severe oligozoospermia // J. Androl. 2009. V. 30, № 6. P. 711—725.
3. Aston K.I., Krausz C., Laface I. et al. Evaluation of 172 can-didate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent // Hum Reprod. 2010. V. 25. № 6. P. 1383—1397.
4. Berkovits B.D., Wolgemuth D.J. The first bromodomain of the testis-specific double bromodomain protein Brdt is required for chromocenter organization that is modulated by genetic background // Dev. Biol. 2011. [published ahead of print].
5. Ferlin A., Arredi B., Foresta C. Genetic causes of male in-fertility // Reprod Toxicol. 2006. V. 22, № 2. P. 133—141.
6. Moriniere J., Rousseaux S., Steuerwald U. et al. Coopera-tive binding of two acetylation marks on a histone tail by a single bromodomain // Nature. 2009. V. 461, № 7264. P. 664—668.
7. Plaseski T., Noveski P., Popeska Z. et al. Association Study of Single Nucleotide Polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR and TAS2R38 Genes with Male Infertility // J. Androl. 2011. [published ahead of print].
8. Pivot-Pajot C., Caron C., Govin J. et al. Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein // Mol. Cell. Biol. 2003. V. 23, № 15. P. 5354—5365.
9. Shang E., Nickerson H.D., Wen D. et al. The first bromo-domain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiation // Development. 2007. V. 134, № 19. P. 3507—3515.
Review
For citations:
Wainer A.S., Nagaitsev V.M., Korolkova O.V., Vostrikov V.V., Osadchuk L.V., Pechkovsky Ye.V., Malinovskaya I.S., Filipenko M.L. Polymorphism rs3088232 in the BRDT gene is associated with idiopathic male infertility in the West Siberian Region of Russia. Bulletin of Siberian Medicine. 2012;11(3):18-21. (In Russ.) https://doi.org/10.20538/1682-0363-2012-3-18-21
Views:
831
Email this article 