Comparative assessment of hepatoprotective effects of various liposome formulations in experimental venous congestion-induced chronic liver insufficiency
https://doi.org/10.20538/1682-0363-2012-4-130-135
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Abstract
The aim of the study was to evaluate the efficacy of lecithin/cholesterol liposomes in the therapy of experimental venous congestion-induced chronic liver insufficiency. The effects of the empty liposomes, ATP and phosphocreatine-containing liposomes and alpha-tocopherol and superoxide dismutase-containing liposomes were studied. It was found that liposomal drugs have a hepatoprotective effect, i.e. they decrease blood enzyme activity (cytolysis markers), reduce oxidative stress and preserve histologic integrity of the liver.
About the Authors
R. A. Mukhamadiyarov
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
N. L. Vorontsova
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
V. V. Borisov
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Yu. A. Kudryavtseva
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
I. Yu. Juravleva
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
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Review
For citations:
Mukhamadiyarov R.A., Vorontsova N.L., Borisov V.V., Kudryavtseva Yu.A., Juravleva I.Yu. Comparative assessment of hepatoprotective effects of various liposome formulations in experimental venous congestion-induced chronic liver insufficiency. Bulletin of Siberian Medicine. 2012;11(4):130-135. (In Russ.) https://doi.org/10.20538/1682-0363-2012-4-130-135
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ISSN 1682-0363 (Print)
ISSN 1819-3684 (Online)
ISSN 1819-3684 (Online)
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