Hepatic stellate cells and their role in the formation of the progenitor cell niche
https://doi.org/10.20538/1682-0363-2024-1-126-133
Abstract
The processes of proliferation and differentiation of progenitor and stem cells in the body are ensured by a specific microenvironment, the stem cell niche. Universal components have been identified for all niches: supporting cells, extracellular matrix, and soluble biological factors. A niche is a dynamic system whose activity depends on regeneration needs.
The review presents data on the structure of the hepatic stem cell niche and one of its main components – stellate cells and their role in pathology.
About the Authors
V. V. Zhdanov
Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIPRM), Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
3, Lenina Av., Tomsk, 634028
A. V. Chaikovskii
Goldberg Research Institute of Pharmacology and Regenerative Medicine (GRIPRM), Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences
Russian Federation
Russian Federation
3, Lenina Av., Tomsk, 634028
E. S. Pan
Research Institute of General Pathology and Pathophysiology
Russian Federation
Russian Federation
8, Baltiyskaya Str., Moscow, 125315
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Review
For citations:
Zhdanov V.V., Chaikovskii A.V., Pan E.S. Hepatic stellate cells and their role in the formation of the progenitor cell niche. Bulletin of Siberian Medicine. 2024;23(1):126-133. https://doi.org/10.20538/1682-0363-2024-1-126-133
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