DEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID
https://doi.org/10.20538/1682-0363-2014-3-56-62
Abstract
The aim of investigation was to study the effect of a gamma-aminobutyric acid´s derivative – a compound RGPU-242 – on the mental development of the rat´s offspring with experimental preeclampsia. Famels’s preeclampsia was modeled by replacing the drinking water of 1.8% sodium chloride solution from 7th to the 21th day of gestation. Locomotion, indicative and emotional activity and cognitive functions in progeny were recorded on “Open field”, “One-way step-down inhibitory (“passive”) avoidance”, “Elevated plus maze” and “Test of extrapolative escape” tests in different periods of postnatal development. Found that the compound RGPU-242 has gravidoprotective effect, improves formation and development of mental functions in the offspring.
About the Authors
I. N. Tyurenkov
Volgograd State Medical University, Volgograd
Russian Federation
Tyurenkov Ivan N.
Russian Federation
Tyurenkov Ivan N.
V. N. Perfilova
Volgograd State Medical University, Volgograd
Russian Federation
Perfilova Valentina N.
Russian Federation
Perfilova Valentina N.
L. I. Mikhailova
Volgograd State Medical University, Volgograd
Russian Federation
Mikhailova Lyudmila I.
Russian Federation
Mikhailova Lyudmila I.
G. A. Zhakupova
Volgograd State Medical University, Volgograd
Russian Federation
Zhakupova Gul'nara A.
Russian Federation
Zhakupova Gul'nara A.
S. A. Lebedeva
Volgograd State Medical University, Volgograd
Russian Federation
Lebedeva Svetlana A.
Russian Federation
Lebedeva Svetlana A.
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Review
For citations:
Tyurenkov I.N., Perfilova V.N., Mikhailova L.I., Zhakupova G.A., Lebedeva S.A. DEVIATIONS IN MENTAL DEVELOPMENT OF THE OFFSPRING OF RATS WITH EXPERIMENTAL PREECLAMPSIA AND THEIR CORRECTION BY NEW DERIVATIVE OF GAMMA-AMINOBUTYRIC ACID. Bulletin of Siberian Medicine. 2014;13(3):56-62. (In Russ.) https://doi.org/10.20538/1682-0363-2014-3-56-62
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