Clinical and anamnestic characteristics of patients depending on left ventricular ejection fraction: results of a register study
P. G. Parfenov,
A. V. Yurkina,
D. P. Golubovskaya,
S. Y. Shuster,
E. V. Dren,
Y. I. Guselnikova,
N. B. Lebedeva,
T. B. Pecherina https://doi.org/10.20538/1682-0363-2024-2-83-90
Abstract
Aim. To study the clinical and anamnestic features of patients followed up in the Center for Chronic Heart Failure at the Regional Vascular Center according to the data of the corresponding register.
Materials and methods. The study included data of 802 patients included in the Kuzbass Register of Patients Followed up at the Center for Chronic Heart Failure from 2020 to 2022. The median follow-up was 1.6 ± 0.7 years.
Results. According to the present register, men dominated in the gender profile of patients with chronic heart failure – 612 (76.3%) participants (p < 0.001). The largest group of subjects was represented by patients with a low left ventricular ejection fraction (less than 40%) – 546 people. This category was also characterized by a more severe functional class of chronic heart failure (New York Heart Association); patients with functional class III– IV chronic heart failure prevailed (p < 0.001).
The most common comorbidities revealed were chronic kidney disease (glomerular filtration rate of less than 60 ml / min / 1.73 m2 according to the CKD-EPI equation) – 614 (76.5%) patients and obesity (body mass index of more than 30 kg / m2) – 334 (41.6%) patients. Type 2 diabetes mellitus was reported in 193 (24%) patients. The analysis of the etiology of chronic heart failure showed that the main causes of heart failure in the groups with low and intermediate left ventricular ejection fraction were coronary heart disease and combined causes, whereas in the group with preserved left ventricular ejection fraction, the disease resulted from coronary heart disease and arrhythmogenic causes.
Conclusion. Assessing the clinical and anamnestic features of patients with heart failure, it can be said that these people are mainly male, retired, with coronary heart disease, low left ventricular ejection fraction, and a comorbidity, mainly chronic kidney disease, diabetes mellitus, and obesity.
About the Authors
P. G. Parfenov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
A. V. Yurkina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
D. P. Golubovskaya
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
S. Y. Shuster
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
E. V. Dren
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
Y. I. Guselnikova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
N. B. Lebedeva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
T. B. Pecherina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Competing Interests:
Russian Federation
6, Sosnovy Blvd., Kemerovo, 650000
Competing Interests:
The authors declare the absence of obvious or potential conflict of interest related to the publication of this article.
References
1. Ziaeian B., Fonarow G.C. Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 2016;13(6):368–378. DOI: 10.1038/nrcardio.2016.25.
2. Kurmani S., Squire I. Acute Heart Failure: Definition, Classification and Epidemiology. Curr. Heart Fail. Rep. 2017;14(5):385–392. DOI: 10.1007/s11897-017-0351-y.
3. Подобед И.В., Прощаев К.И., Ахмедов Т.А., Рукавишников А.С., Коваленко О.Ю. Гериатрические аспекты течения хронической сердечной недостаточности. Современные проблемы здравоохранения и медицинской статистики. 2021;(1):303–325. DOI: 10.24411/2312-2935-2021-00022.
4. Nguyen Trung M.L., Ancion A., Lancellotti P. Vignette diagnostique de l’étudiant. Approche diagnostique clinique d’une insuffisance cardiaque. Clinical diagnostic approach for heart failure. Rev. Med. Liege. 2022;77(1):69–74. (In French).
5. Поляков Д.С., Фомин И.В., Беленков Ю.Н., Мареев В.Ю., Агеев Ф.Т., Артемьева Е.Г. и др. Хроническая сердечная недостаточность в Российской Федерации: что изменилось за 20 лет наблюдения? Результаты исследования ЭПОХА–ХСН. Кардиология. 2021;61(4):4–14. DOI: 10.18087/cardio.2021.4.n1628.
6. Фомин И.В. Хроническая сердечная недостаточность в Российской Федерации: что сегодня мы знаем и что должны делать. Российский кардиологический журнал. 2016;21(8):7–13. DOI: 10.15829/1560-4071-2016-8-7-13.
7. Виноградова Н.Г. Городской центр лечения хронической сердечной недостаточности: организация работы и эффективность лечения пациентов с хронической сердечной недостаточностью. Кардиология. 2019;59(2S):31–39. DOI: 10.18087/cardio.2621.
8. Lam C.S.P., Arnott C., Beale A.L., Chandramouli C., Hilfiker-Kleiner D., Kaye D.M. et al. Sex differences in heart failure. Eur. Heart J. 2019;40(47):3859–3868c. DOI: 10.1093/eurheartj/ehz835.
9. Savarese G., D’Amario D. Sex differences in heart failure. Adv. Exp. Med. Biol. 2018;1065:529–544. DOI: 10.1007/978-3-319-77932-4_32.
10. Дадашова Г.М. Гендерные особенности хронической сердечной недостаточности. Клиническая медицина. 2015;93(1):71–75.
11. Morgan H., Sinha A., Mcentegart M., Hardman S.M., Perera D. Evaluation of the causes of sex disparity in heart failure trials. Heart. 2022;108(19):1547–1552. DOI: 10.1136/heartjnl-2021-320696.
12. Мышляева Т.О., Постникова С.Л., Кисляк О.А. Хроническая сердечная недостаточность у женщин. Лечебное дело. 2018;(2):59–64. DOI: 10.24411/2071-5315-2018-12003.
13. Crespo-Leiro M.G., Metra M., Lund L.H., Milicic D., Costanzo M.R., Filippatos G. et al. Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 2018;20(11):1505–1535. DOI: 10.1002/ejhf.1236.
14. Dharmarajan K., Rich M.W. Epidemiology, pathophysiology, and prognosis of heart failure in older adults. Heart Fail. Clin. 2017;13(3):417–426. DOI: 10.1016/j.hfc.2017.02.001.
15. Skrzypek A., Mostowik M., Szeliga M., Wilczyńska-Golonka M., Dębicka-Dąbrowska D., Nessler J. Chronic heart failure in the elderly: still a current medical problem. Folia Med. Cracov. 2018;58(4):47–56.
16. Savarese G., Stolfo D., Sinagra G., Lund L.H. Heart failure with mid-range or mildly reduced ejection fraction. Nat. Rev. Cardiol. 2022;19(2):100–116. DOI: 10.1038/s41569-021-00605-5.
17. Murphy S.P., Ibrahim N.E., Januzzi J.L. Jr. Heart Failure with Reduced Ejection Fraction: A Review. JAMA. 2020;324(5):488–504. DOI: 10.1001/jama.2020.10262.
18. Borlaug B.A. Evaluation and management of heart failure with preserved ejection fraction. Nat. Rev. Cardiol. 2020;17(9):559–573. DOI: 10.1038/s41569-020-0363-2.
19. Obokata M., Reddy Y.N.V., Pislaru S.V., Melenovsky V., Borlaug B.A. Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation. 2017;136(1):6–19. DOI: 10.1161/CIRCULATIONAHA.116.026807.
20. Faggiano P., Bernardi N., Calvi E., Bonelli A., Faggiano A., Bursi F. et al. Stage A heart failure: Modern strategies for an effective prevention. Heart Fail. Clin. 2021;17(2):167–177. DOI: 10.1016/j.hfc.2021.01.004.
21. Barnhouse K. Heart Failure: Heart failure with reduced ejection fraction. FP Essent. 2021;506:20–26.
22. Del Buono M.G., Moroni F., Montone R.A., Azzalini L., Sanna T., Abbate A. Ischemic cardiomyopathy and heart failure after acute myocardial infarction. Curr. Cardiol. Rep. 2022;24(10):1505–1515. DOI: 10.1007/s11886-022-01766-6.
23. Окунев И.М., Кочергина А.М., Кашталап В.В. Хроническая и острая декомпенсированная сердечная недостаточность: актуальные вопросы. Комплексные проблемы сердечнососудистых заболеваний. 2022;11(2):184–195. DOI: 10.17802/2306-1278-2022-11-2-184-195.
24. Pecherina T., Kutikhin A., Kashtalap V., Karetnikova V., Gruzdeva O., Hryachkova O. et al. Serum and echocardiographic markers may synergistically predict adverse cardiac remodeling after ST-segment elevation myocardial infarction in patients with preserved ejection fraction. Diagnostics (Basel). 2020;10(5):301. DOI: 10.3390/diagnostics10050301.
25. Зотова О.В., Денисевич Т.Л., Курлянская Е.К., Ревтович О.П. Эпидемиология хронической сердечной недостаточности в городе Минске. Евразийский кардиологический журнал. 2016;(3):182–183.
Review
For citations:
Parfenov P.G., Yurkina A.V., Golubovskaya D.P., Shuster S.Y., Dren E.V., Guselnikova Y.I., Lebedeva N.B., Pecherina T.B. Clinical and anamnestic characteristics of patients depending on left ventricular ejection fraction: results of a register study. Bulletin of Siberian Medicine. 2024;23(2):83-90. https://doi.org/10.20538/1682-0363-2024-2-83-90
Views:
297
Email this article 