HETEROTOPIC TRANSPLANTATION OF HEART AND THE REGULATORY MECHANISMS OF THE ADAPTATION
https://doi.org/10.20538/1682-0363-2016-3-5-9
Abstract
Aim. The article describes the results of an experimental study of the adaptation mechanisms of heart and transplant (cardio-pulmonary complex, CPC) in heterotopic transplantation.
Materials and methods. CPC`s from recipients (8 dogs) were transplanted in left oblique-diaphragmatic sinus of donor`s (8 dogs). As a results of parallel connection transplant pre- and post-load of donor`s heart was reduces. Oxygenated blood by CPC was passed the left chambers of donor`s heart and returned to the aorta. Another part from pulmonary artery shunted to the right chamber of CPC as a result decreased systolic pressure on the right ventricle of heart. During the co-working of CPC and heart was happened synchronization.
Consequently self-regulating process of circulatory system provides mechanism of adaptation in new conditions. The findings are important for understanding the effectiveness and relevance of this bilogical method of circulatory support.
About the Authors
A. N. Baikov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
MD, professor head of Central Research Laboratory
2 Moscow Trakt, Tomsk, 634050
V. E. Tolpekin
Academician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
МD, professor
1 Chukinskuy St., Moscow, 123182
M. A. Medvedev
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
МD, professor, Head of Department Normal Human Physiology
2 Moscow Trakt, Tomsk, 634050
E. V. Semichiev
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
PhD, researcher of central research laboratory
2 Moscow Trakt, Tomsk, 634050
S. D. Ivanov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
5th year student, Faculty of Pediatrics
2 Moscow Trakt, Tomsk, 634050
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Review
For citations:
Baikov A.N., Tolpekin V.E., Medvedev M.A., Semichiev E.V., Ivanov S.D. HETEROTOPIC TRANSPLANTATION OF HEART AND THE REGULATORY MECHANISMS OF THE ADAPTATION. Bulletin of Siberian Medicine. 2016;15(3):5-9. (In Russ.) https://doi.org/10.20538/1682-0363-2016-3-5-9
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