Study of the spectrum of unsaturated fatty acids in the blood of men with diabetes mellitus in Novosibirsk (ESSE-RF3 in the Novosibirsk region)
V. S. Shramko,
G. I. Simonova,
L. V. Shcherbakova,
A. D. Afanasieva,
J. A. Balanova,
A. E. Imaeva,
S. A. Shalnova,
Yu. I. Ragino https://doi.org/10.20538/1682-0363-2025-1-124-133
Abstract
Aim. To study the content of unsaturated fatty acids (FAs) in blood plasma in men from Novosibirsk (ESSERF3 in the Novosibirsk region) with established type 2 diabetes mellitus (DM2), newly diagnosed diabetes, and prediabetes, as well as to evaluate the associations of various types of FAs with the presence or absence of diabetes and fasting glucose levels.
Materials and methods. Within the framework of the multicenter, single-stage epidemiological ESSE-RF3 study in the Novosibirsk region, 1 200 residents of Novosibirsk (600 men, 600 women) aged 35–74 years were examined. The present study included 563 men with an average age of 54.4 ± 11.48 years, comprising: 61 individuals diagnosed with DM2 based on anamnestic data (Group I); 65 men with newly diagnosed diabetes (Group II); 46 men with conditional prediabetes (Group III); and 391 men without diabetes – (Group IV). The levels of unsaturated FAs in blood plasma were determined via high-performance liquid chromatography.
Results. An increase in omega-3, -6, and -9 FA levels was revealed in Group I compared to Group IV. An increase in the level of oleic acid (p = 0.040) was found in Group II compared to Group IV. The relative chance of DM2 is directly associated with an increase in the levels of omega-3 alpha-linolenic acid (odds ratio (OR) = 1.030, 95 confidence interval (CI) 1.002–1.058; p = 0.034) and omega-6 gamma-linolenic acid (OR = 1.026, 95 CI 1.001–1.051; p = 0.044). Newly diagnosed diabetes is inversely associated with the level of linoleic acid in blood plasma (OR = 0.545, 95 CI 0.301–0.996; p = 0.048), as well as directly associated with the level of oleic acid (OR = 1.961, 95 CI 1.054–3.648; p = 0.034). Prediabetes is inversely associated with the level of hexadecenoic acid (OR = 0.969, 95 CI 0.943–0.996; p = 0.025).
Conclusion. Detection of changes in the profile of unsaturated FAs in blood plasma can be used as an additional prognostic biomarker to identify patients at risk of developing DM.
Supporting agencies: The work was carried out within the framework of ESSE-RF3 for the Novosibirsk region and a budget topic for State assignment No. FWNR-2024-0004.
About the Authors
V. S. Shramko
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences (IIPM – Branch of IC&G SD of RAS)
Russian Federation
Competing Interests:
Russian Federation
175/1 B. Bogatkov Str., Novosibirsk, 630089
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
G. I. Simonova
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences (IIPM – Branch of IC&G SD of RAS)
Russian Federation
Competing Interests:
Russian Federation
175/1 B. Bogatkov Str., Novosibirsk, 630089
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences (IIPM – Branch of IC&G SD of RAS)
Russian Federation
Competing Interests:
Russian Federation
175/1 B. Bogatkov Str., Novosibirsk, 630089
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
A. D. Afanasieva
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences (IIPM – Branch of IC&G SD of RAS)
Russian Federation
Competing Interests:
Russian Federation
175/1 B. Bogatkov Str., Novosibirsk, 630089
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
J. A. Balanova
Federal State Budgetary Institution National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
10, Bldg. 3, Petroverigsky Lane, Moscow, 101990
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
A. E. Imaeva
Federal State Budgetary Institution National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
10, Bldg. 3, Petroverigsky Lane, Moscow, 101990
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
S. A. Shalnova
Federal State Budgetary Institution National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Russian Federation
Competing Interests:
Russian Federation
10, Bldg. 3, Petroverigsky Lane, Moscow, 101990
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences (IIPM – Branch of IC&G SD of RAS)
Russian Federation
Competing Interests:
Russian Federation
175/1 B. Bogatkov Str., Novosibirsk, 630089
Competing Interests:
The authors declare the absence of obvious or potential conflicts of interest related to the publication of this article.
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Shramko V.S., Simonova G.I., Shcherbakova L.V., Afanasieva A.D., Balanova J.A., Imaeva A.E., Shalnova S.A., Ragino Yu.I. Study of the spectrum of unsaturated fatty acids in the blood of men with diabetes mellitus in Novosibirsk (ESSE-RF3 in the Novosibirsk region). Bulletin of Siberian Medicine. 2025;24(1):124-133. https://doi.org/10.20538/1682-0363-2025-1-124-133
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