Protein analysis capabilities in the NCBI bioinformation system

N. Yu. Chasovskikh

doi:10.20538/1682-0363-2025-4-194-203

Protein analysis capabilities in the NCBI bioinformation system

N. Yu. Chasovskikh

https://doi.org/10.20538/1682-0363-2025-4-194-203

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Abstract

Aim. To review and summarize information about the features of protein data storage, as well as the possibilities for their analysis using NCBI tools.

The lecture summarizes data on existing repositories of protein sequences and structures, and analyzes the capabilities of bioinformatics tools for protein research on the NCBI platform (National Center for Biotechnology Information). The primary databases contain information about proteins (records) obtained through experimental studies; in addition, databases with supplementary information added by curators after analysis are also presented. Furthermore, bioinformatic analysis of protein sequences and structures using the tools discussed in this lecture enables the identification of phylogenetic features, as well as the prediction of functions and structures. Thus, the extraction of extensive information and its analysis through specialized services facilitate insights into in silico research of experimentally undetected protein characteristics, providing new knowledge that forms the basis for further investigations.

Keywords

bioinformatics, protein sequence, domain, alignment, three-dimensional structure, NCBI

About the Author

N. Yu. Chasovskikh

Siberian State Medical University (SibSMU)
Russian Federation

2 Moskovsky trakt, 634050 Tomsk

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Review

For citations:

Chasovskikh N.Yu. Protein analysis capabilities in the NCBI bioinformation system. Bulletin of Siberian Medicine. 2025;24(4):194-203. (In Russ.) https://doi.org/10.20538/1682-0363-2025-4-194-203

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