Gene ontology for genomics and biology
https://doi.org/10.20538/1682-0363-2026-1-176-184
Abstract
The aim of the lecture was to consider the role of gene ontology (GO) and the GO Consortium in shaping the knowledge base for genomics, proteomics, and biology. GO organizes and continually updates data on the molecular functions and biological processes in which genes and their products are involved.
The structure of GO, the features of GO term hierarchy and the connections between them, as well as the elements of each term are considered. The features of services for working with basic knowledge and various ways to access civil defense data are given. In addition to term characteristics, GO pays great attention to annotations – statements that link a gene product to a certain ontology term. The annotation process captures the action and location of a gene product using terms, providing a reference and a type of evidence.
The areas of application of GO related to the analysis of genomics and proteomics data are considered. The main approaches used by researchers are functional annotation of genes and pathway enrichment analysis. Analysis of large volumes of data (for example, when assessing gene expression) allows to gain knowledge about the involvement of genes and their products in various processes, extract biological meaning, and evaluate the features of molecular mechanisms in various diseases. The increasing role of GO in the formation of new knowledge in the relevant field is shown.
About the Author
N. Yu. Chasovskikh
Siberian State Medical University
Russian Federation
Russian Federation
2 Moscovsky trakt, 634050 Tomsk, Russian Federation
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Chasovskikh N.Yu. Gene ontology for genomics and biology. Bulletin of Siberian Medicine. 2026;25(1):176-184. https://doi.org/10.20538/1682-0363-2026-1-176-184
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