The role of systemic inflammatory indices in predicting carotid atherosclerosis in patients with rheumatoid arthritis
https://doi.org/10.20538/1682-0363-2026-2-49-57
Abstract
Aim. To determine the prognostic significance of systemic inflammatory indices for the development of carotid artery (CA) atherosclerosis in patients with rheumatoid arthritis (RA).
Materials and methods. A single-center, observational, cross-sectional study was conducted, which included 52 male and female patients with RA. The average age of the study participants was 59.5 ± 6.7 years. All patients underwent carotid duplex ultrasound. The intima-media thickness was recorded at ≥ 0.9 mm. A hemodynamically significant atherosclerotic plaque (AP) was considered to be a CA thickening of more than 50% compared to adjacent tissues. Based on the general blood test data, the systemic inflammatory response index (SIRI), the aggregate index of systemic inflammation (AISI), the systemic immune-inflammation index (SII), the neutrophil-lymphocyte ratio (NLR), the lymphocyte-monocyte ratio (LMR), the platelet-lymphocyte ratio (PLR), and the Reys leukocyte index of intoxication were calculated. Binary logistic regression was used to develop a prognostic model.
Results. Based on the results of the carotid duplex ultrasound, the patients were divided into 2 groups: 32 patients (61.5%) with the presence of AP in the CA and 20 patients (38.5%) without AP. Patients with AP in the CA had higher values of NLR, SII, SIRI, and the Reys leukocyte index of intoxication. During the study, threshold values for these indices were determined, and a prognostic model for the probability of developing atherosclerosis of the CA in patients with RA was developed, in which the predictors were the values of the Reys index, SIRI, low density lipoproteins, and age.
Conclusion. In RA, high activity of systemic inflammation is associated with the development of atherosclerotic arterial lesions, which should be taken into account when determining the tactics of managing these patients.
About the Authors
A. A. Kononykhin
National Ilizarov Medical Research Center for Traumatology and Orthopedics;
Kurgan Regional Clinical Hospital
Russian Federation
Russian Federation
6 M. Ulyanov St., 640014 Kurgan, Russian Federation
63 Tomin St., 640002 Kurgan, Russian Federation
E. V. Zhdanova
National Ilizarov Medical Research Center for Traumatology and Orthopedics;
Tyumen State Medical University
Russian Federation
Russian Federation
6 M. Ulyanov St., 640014 Kurgan, Russian Federation
54 Odesskaya St., 625023 Tyumen, Russian Federation
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For citations:
Kononykhin A.A., Zhdanova E.V. The role of systemic inflammatory indices in predicting carotid atherosclerosis in patients with rheumatoid arthritis. Bulletin of Siberian Medicine. 2026;25(2):49-57. https://doi.org/10.20538/1682-0363-2026-2-49-57
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