METALLOTHIONEINS AS SENSORS AND CONTROLS EXCHANGE OF METALS IN THE CELLS
https://doi.org/10.20538/1682-0363-2014-3-91-99
Abstract
The basic information on the classification, structure, induction and degradation, functions of the protein family – metallothionein (MT), including CNS in health and disease are presented in this review. It was found that four major isoforms of metallothionein perform different biological roles, are localized in dif- ferent tissues. Induction of MT is a universal reaction to the impact of a variety of stress factors. In recent years, understanding of the role of metallothioneins in metal homeostasis in the tissues in normal and pathological conditions have changed significantly. Notes polyfunctionality metallothioneins (transport of metal ions, maintaining redox reactions, tread, signal, modulated and regulatory functions) and their im- pact on basic cellular functions such as proliferation, differentiation, programmed cell death. Further- more, a special role is shown MT in the pathogenesis of cardiovascular, neurodegenerative and neoplastic disorders.
Currently, these molecules are increasingly considered as potential targets for therapy of a wide range of diseases and the development of targeted approaches to the regulation of expression of MT – one of the promising areas of pharmacology and toxicology. Stressed the safety of metallothioneins as therapeutic agents.
About the Authors
V. A. Kutyakov
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Kutyakov Victor A.
Russian Federation
Kutyakov Victor A.
A. V. Salmina
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Salmina Alla B.
Russian Federation
Salmina Alla B.
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Review
For citations:
Kutyakov V.A., Salmina A.V. METALLOTHIONEINS AS SENSORS AND CONTROLS EXCHANGE OF METALS IN THE CELLS. Bulletin of Siberian Medicine. 2014;13(3):91-99. (In Russ.) https://doi.org/10.20538/1682-0363-2014-3-91-99
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