Olfactory dysfunction and modification in microbiota as early non-motor manifestations of Parkinson’s disease
https://doi.org/10.20538/1682-0363-2016-5-66-74
Abstract
The purpose of this paper is to study the most common non-motor symptoms of the Parkinson’s disease (PD): olfactory dysfunction, constipation and associated with them variety of fecal microorganisms in patients with Parkinson’s disease.
Materials and methods. We studied olfactory function in 51 patients with PD using Sniffin Sticks Test and taxonomic composition of fecal microbiota.
Results. Olfactory dysfunctions (hyposmia, anosmia) were found in most patients that participated in study as well as differences in alpha-variety of gut microbiota among groups with different olfactory characteristics.
Conclusion. Our findings suggest that the composition of gut microbiota must be associated with etiology and pathogenesis of PD.
About the Authors
E. S. Kostryukova
Research Institute of Physico-Chemical Medicine of Russian Federal Medico-Biological Agency (RIPCM)
Russian Federation
Russian Federation
PhD, Head of Laboratory Postgenomics Research in Biology,
1а, Malaya Pirogovskaya Str., Mosсow, 119992
V. M. Alifirova
Siberian State Medical University
Russian Federation
Russian Federation
MD, Professor, Head of the Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
N. G. Zhukova
Siberian State Medical University
Russian Federation
Russian Federation
MD, Professor, Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
I. A. Zhukova
Siberian State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
O. P. Izhboldina
Siberian State Medical University
Russian Federation
Russian Federation
Post-graduate Student,
2, Moscow Trakt, Tomsk, 634050
V. A. Petrov
Siberian State Medical University
Russian Federation
Russian Federation
Junior Researcher, Central Research Laboratory,
2, Moscow Trakt, Tomsk, 634050
Yu. S. Mironova
Siberian State Medical University
Russian Federation
Russian Federation
Post-graduate Student, Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
A. V. Latypova
Siberian State Medical University
Russian Federation
Russian Federation
Neurology Resident,
2, Moscow Trakt, Tomsk, 634050
M. A. Nikitina
Siberian State Medical University
Russian Federation
Russian Federation
Post-graduate Student, Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
M. A. Titova
Siberian State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Neurology and Neurosurgery Department,
2, Moscow Trakt, Tomsk, 634050
A. V. Tyakht
Research Institute of Physico-Chemical Medicine of Russian Federal Medico-Biological Agency (RIPCM)
Russian Federation
Russian Federation
PhD, Senior Researcher, Laboratory of Bioinformation,
1а, Malaya Pirogovskaya Str., Mosсow, 119992
Yu. B. Dorofeeva
Siberian State Medical University
Russian Federation
Russian Federation
Junior Researcher, Central Research Laboratory,
2, Moscow Trakt, Tomsk, 634050
I. V. Saltykova
Siberian State Medical University
Russian Federation
Russian Federation
PhD, Researcher, Central Research Laboratory,
2, Moscow Trakt, Tomsk, 634050
A. E. Sazonov
Lomonosov Moscow State University
Russian Federation
Russian Federation
MD, Deputy Vice-Rector,
1, Leninskie Gory, Moscow, 119991
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Review
For citations:
Kostryukova E.S., Alifirova V.M., Zhukova N.G., Zhukova I.A., Izhboldina O.P., Petrov V.A., Mironova Yu.S., Latypova A.V., Nikitina M.A., Titova M.A., Tyakht A.V., Dorofeeva Yu.B., Saltykova I.V., Sazonov A.E. Olfactory dysfunction and modification in microbiota as early non-motor manifestations of Parkinson’s disease. Bulletin of Siberian Medicine. 2016;15(5):66-74. (In Russ.) https://doi.org/10.20538/1682-0363-2016-5-66-74
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