Development of endothelial dysfunction at an obliterating atherosclerosis of vessels of the lower extremities and markers of prediction of a course of a disease
https://doi.org/10.20538/1682-0363-2017-1-108-118
Abstract
In this review questions of development of endothelial dysfunction and its influence on progressing of a disease at an obliterating atherosclerosis of vessels of the lower extremities are considered. The role of selektin in adhesion of leukocytes on the endothelial cells leading to inflammatory reaction of a vascular wall is defined. In researches influence of the infectious agent on risk of development of a disease is noted. Decrease in dilatiruyushchy function of an endothelium happens due to deficiency of synthesis of nitrogen oxide. Development of an oxidizing stress and development of the fissile forms of oxygen exerts negative impact on an endothelium. The indicators associated with an atherosclerosis are inflammation mediators, markers of endothelial dysfunction and an angiogenesis, a lipide profile and factors of coagulation.
About the Authors
S. S. Dunaevskaya
Krasnoyarsk State Medical University named after prof. V.F. Voyno-Jaseneckiy
Russian Federation
Russian Federation
DM, Professor of the General Surgery Department named after Prof. M.I. Gulman,
1, Str. Partizana Zsheleznyaka, Krasnoyarsk, 660022
Yu. S. Vinnik
Krasnoyarsk State Medical University named after prof. V.F. Voyno-Jaseneckiy
Russian Federation
Russian Federation
DM, Professor, Head of the General Surgery Department named after Prof. M.I. Gulman,
1, Str. Partizana Zsheleznyaka, Krasnoyarsk, 660022
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Review
For citations:
Dunaevskaya S.S., Vinnik Yu.S. Development of endothelial dysfunction at an obliterating atherosclerosis of vessels of the lower extremities and markers of prediction of a course of a disease. Bulletin of Siberian Medicine. 2017;16(1):108-118. (In Russ.) https://doi.org/10.20538/1682-0363-2017-1-108-118
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