EFFECTS OF PHYSICAL EXERCISES ON TRIACYLGLYCEROL LEVEL IN SKELETAL MUSCLES IN DIETARY-INDUCED OBESE RATS
https://doi.org/10.20538/1682-0363-2014-1-92-97
Abstract
The accumulation of triacylglycerol in peripheral tissues is one of mechanisms of insulin resistance. This paper presents the investigation of the influence of aerobic and anaerobic physical exercises on triacylglycerol level in skeletal muscles and on insulin resistance in dietary-induced obese rats. It is estimated that a high-energy (HE) diet causes the accumulation of triacylglycerols in skeletal muscles that leads to high resistance to insulin. Aerobic and anaerobic physical exercises reduce the level of triacylglycerols in skeletal muscles and raise sensitivity to insulin in obese rats. Physical exercises raise the level of triacylglycerols in skeletal muscles in standard-diet rats that probably is the adaptation to high energy expenditure, but does not lead to high insulin resistance.
About the Authors
I. Yu. Yakimovich
Siberian State Medical University, Tomsk
Russian Federation
Yakimovich Inessa Yu.
Russian Federation
Yakimovich Inessa Yu.
D. A. Borodin
Siberian State Medical University, Tomsk
Russian Federation
Borodin Dmitry A.
Russian Federation
Borodin Dmitry A.
I. K. Podrezov
Siberian State Medical University, Tomsk
Russian Federation
Podrezov Iliya K.
Russian Federation
Podrezov Iliya K.
V. V. Ivanov
Siberian State Medical University, Tomsk
Russian Federation
Ivanov Vladimir V.
Russian Federation
Ivanov Vladimir V.
V. N. Vasiliyev
Siberian State Medical University, Tomsk
Russian Federation
Vasiliyev Vladimir N.
Russian Federation
Vasiliyev Vladimir N.
M. Yu. Kotlovsky
Krasnoyarsk State Medical University, Krasnoyarsk
Russian Federation
Kotlovsky Mikhail Yu.
Russian Federation
Kotlovsky Mikhail Yu.
References
1. Grinevich V.B., Sas E.I., Kravchuk Ju.A., Efimov O.I. Obesity and Metabolism, 2012, no. 2, pp. 28–32 (in Russian).
2. Kononenko I.V., Smirnova O.M. Attending doctor, 2006, no. 2, pp. 12–16 (in Russian).
3. Lupanov V.I. Russian Medical Journal, 2003, vol. 11 (6), pp. 18–24 (in Russian).
4. Obesity: etiology, pathogenesis, clinical aspects. Dedov I.I., Melnichenko G.A. Moscow, МIA Publ., 2006. 452 p. (in Russian).
5. Shvarc V. Problems of Endocrinology, 2009, vol. 55, no. 1, pp. 38–44 (in Russian).
6. Kario К., Nafo N., Kayaba K., Saegusa T., Matsuo H., Goto T. Characteristics of the insulin resistance syndrome in a Japanese population. The Jichi Medical School Cohort Study. Atherosclerosis, Thrombosis and Vascular Biology, 1996, vol. 16, pp. 270–274.
7. Korneyeva O.N. Russian Medical News, 2007, vol. 2, pp. 36–44 (in Russian).
8. Fabbrini E., Sullivan S., Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology, 2010, vol. 51(2), pp. 679 –689.
9. Speliotes E.K., Massaro J.M., Hoffmann U. et al. Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham heart study. Hepatology, 2010, vol. 51(6), pp. 1979–1987.
10. Siharulidze M.D, Dzhanashija N.G, Sanikidze T.V, Gogeshvili S.G. Georgian Medical News, 2006, no. 6 (135), pp. 123–126 (in Russia).
11. West D.B., J. Waguespack S. McCollister. Dietary obesity in the mouse: interaction of strain and diet composition. Am. J. Physiol., 1995, 268, pp. 658–665.
12. Gobatto C.A., Mello MAR, Sibuya C.Y., Azevedo JRM, dos Santos L.A., Kokubun E. Maximal lactate steady state in rats submitted to swimming exercise. Comp Biochem Physiol A Mol Integr Physiol, 2001, 130 (suppl 1), pp. 21–27.
13. Folch J. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 1957, vol. 226, no 1, pp. 497–509.
14. Van Veldhoven P.P. Lipase-based quntitation of triacylglycerols in cellular lipid extracts: requirement for presence of detergent and prior separation by thin-layer chromatography. Lipids, 1997, vol. 32, no. 12, pp. 1297– 1300.
15. Van Loon L.J., Koopman R., Stegen J.H., Wagenmakers A.J., Keizer H.A., Saris W.H. Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance trained males in a fasted state. J. Physiol., 2003, Dec. 1, vol. 553 (Pr), pp. 611–625.
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For citations:
Yakimovich I.Yu., Borodin D.A., Podrezov I.K., Ivanov V.V., Vasiliyev V.N., Kotlovsky M.Yu. EFFECTS OF PHYSICAL EXERCISES ON TRIACYLGLYCEROL LEVEL IN SKELETAL MUSCLES IN DIETARY-INDUCED OBESE RATS. Bulletin of Siberian Medicine. 2014;13(1):92-97. (In Russ.) https://doi.org/10.20538/1682-0363-2014-1-92-97
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