RADIONUCLIDE INDICATION OF SENTINEL LYMPH NODES IN LARYNX AND LARYNGOPHARYNX CANCER
https://doi.org/10.20538/1682-0363-2014-1-116-121
Abstract
Aim: to determine the possibility of radionuclide methods in the identification of "sentinel" lymph node (SLN) in larynx and laryngopharynx cancer patients.
Material and methods: 17 patients with larynx and laryngopharynx cancer were included in research. In all patients for SLN visualization nanocolloid radiopharmaceutical was injection around tumor into mucous coat with the subsequent SPECT and radioguided study.
Results: Sensitivity and specificity of SPECT and radioguided study for SLN identification were 100%. We found 22 SLN in 17 patients (from 1 to 2 per patient, on average 1.3). Most often SLN were located in the III level of a neck (lymph nodes around of carotid arteries) – 12 SLN (54.5%) and IIA level (under lower jaw lymph nodes) – 6 (27.2%). One SLN (4.5%) was localized in IV level and 3 nodes (13.6%) in VI level. In 2 patients (11.8%) metastasis in SLN were found. In these patients within 2 years cancer progressing was revealed. Fifteen patients (88.2%) had no metastatic in SLN and had no progressing of a cancer.
Conclusions: Sensitivity and specificity of SPECT and radioguided study for SLN identification are 100%. In patients with metastatic SLN radical surgery with lymph node dissection is helpful.
About the Authors
I. G. Sinilkin
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Sinilkin Ivan G.
Russian Federation
Sinilkin Ivan G.
V. I. Chernov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Chernov Vladimir I.
Russian Federation
Chernov Vladimir I.
Ye. L. Choinzonov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk; Siberian State Medical University, Tomsk
Russian Federation
Choinzonov Yevgeny L.
Russian Federation
Choinzonov Yevgeny L.
S. Yu. Chizhevskaya
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Chizhevskaya Svetlana Yu.
Russian Federation
Chizhevskaya Svetlana Yu.
A. A. Titskaya
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Titskaya Anna A.
Russian Federation
Titskaya Anna A.
R. V. Zelchan
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Zelchan Roman V.
Russian Federation
Zelchan Roman V.
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Review
For citations:
Sinilkin I.G., Chernov V.I., Choinzonov Ye.L., Chizhevskaya S.Yu., Titskaya A.A., Zelchan R.V. RADIONUCLIDE INDICATION OF SENTINEL LYMPH NODES IN LARYNX AND LARYNGOPHARYNX CANCER. Bulletin of Siberian Medicine. 2014;13(1):116-121. (In Russ.) https://doi.org/10.20538/1682-0363-2014-1-116-121
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