Pulmonary histocytosis X: clinical observation of early-stage disease
https://doi.org/10.20538/1682-0363-2017-2-195-201
Abstract
Histocytosis X is a rare disease of unknown etiology involving the reticuloendothelial system. We present a case of a 32 year-old man diagnosed with Pulmonary Histocytisis X. The CT image of the lungs showed disseminated disease with the formation of cyst-like cavities, which were histologically verified using lung biopsy.
About the Authors
Irina G. Frolova
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Professor, Head of the Diagnostic Imaging Department
12/а, Savinuh Str., 634028, Tomsk
Svetlana A. Velichko
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Professor, Principal Investigator, Imaging Department
12/а, Savinuh Str., 634028, Tomsk
Aleksey V. Goldberg
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
Junior Researcher, Diagnostic Imaging Department
12/а, Savinuh Str., 634028, Tomsk
Sergey A. Tuzikov
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Professor, Head of Thoracic and Abdominal Department
12/а, Savinuh Str., 634028, Tomsk
Sergey A. Miller
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Leading Researcher, Thoracic and Abdominal Department
12/а, Savinuh Str., 634028, Tomsk
Evgeniy O. Rodionov
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
Postgraduate Student, Thoracic and Abdominal Department
12/а, Savinuh Str., 634028, Tomsk
Leonid A. Efteev
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
Junior Researcher, Thoracic and Abdominal Department
12/а, Savinuh Str., 634028, Tomsk
Ludmila N. Bondar
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
PhD, Doctor, Department of Pathological Anatomy and Cytology
12/а, Savinuh Str., 634028, Tomsk
Vladimir M. Perelmuter
Tomsk Cancer Research Institute, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)
Russian Federation
Russian Federation
DM, Professor, Head of Department of Pathological Anatomy and Cytology
12/а, Savinuh Str., 634028, Tomsk
References
1. Ilkovich M.M., Kokosova A.N. Intersticialnie zabolevanja legkih [Interstitial diseases of lungs]. SPb.: Nordmedizdat Publ., 2005: 560 (in Russian).
2. Mason R.H., Foley N.M. et al. Pulmonary Langerhans cell histiocytosis (PLCH): a new UK register // Thorax. 2014; 69 (8): 766–768.
3. Aydoğdu K. et al. Pulmonary Langerhans cell histiocytosis // Tuberk. Toraks. 2013; 61 (4): 333–341.
4. Abbott G.F., Rosado-de-Christenson M.L., Franks T.J. et al. Pulmonary Langerhans cell histiocytosis // Radio Graphics. 2004; 24 (8): 821–841.
5. Tazi A. Adult pulmonary Langerhans’ cell histiocytosis // Eur. Respir. J. 2006; 27 (6): 1272–1285.
6. Caminati A., Harari S. Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis // Proc. Am. Thorac. Soc. 2006; 3 (4): 299–306.
7. Kambouchner M., Basset F., Marchal J. et al. Threedimensional characterization of pathologic lesions in pulmonary Langerhanscell histiocytosis // Am. J. Respir. Crit. Care Med. 2002; 166 (10): 1483–1490.
8. Westerlaan H.E. et al. Clinical and radiological evolution in patients with pulmonary Langerhans’ call histiocytosis // Netherlands J. Med. 2002; 60 (8): 320–326.
9. Attili A.K., Kazerooni E.A., Gross B.H. et al. Smoking-related interstitial lung disease: radiologicclinicalpathologic correlation // Radio Graphics. 2009; 28 (5): 1383–1398.
10. Chun-hua L., Cheng J.I., Raymond D.P. et al. Uncommon features of pulmonary Langerhans’ cell histiocytosis: analysis of 11 cases and a review of the literature // Chin. Med. J. 2010; 123 (4): 498–501.
11. Fukuda Y. et al. // Eur. J. Prev. Cardiol. 2013; Jul 29 [Epub ahead of print].
12. Vassallo R., Jensen E.A., Colby T.V. The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: highresolution CT, histologic, and functional correlations // Chest. 2003; 124 (4): 1199–1205.
13. Amosov V.V. Komputernaja tomografija v ocenke perestroiki legochnoi tkani u bolnih gistiocitozom X [Computer tomography in an assessment of reorganization of pulmonary fabric at patients with Histiocytosis X] // Medicinskaja vizualizacija – Medical Visualization. 2014; 3: 27–31 (in Russian).
14. Juvet S.C., Hwang D., Downey G.P. Rare lung diseases III: Pulmonary Langerhans’ cell histiocytosis // Can. Respir. J. 2010; 17 (3): 55–62.
15. Ribakov M.G., Dvorkovsky I.V., Baikov V.V., Markusevich E.V. Immunomorfologicheskaja harakteristika gistiocitoza iz kletok Langerganca v legkih [Immunomorphological characteristics of histiocytosis from Langerhans cells in the lungs ] // Archiv patalogii – Archive of Pathology. 2008; 70 (4): 3–5 (in Russian).
16. Girschikofsky M. et. al. Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net // Orphanet. J. Rare Dis. 2013; 8 (1): 72–82.
Review
For citations:
Frolova I.G., Velichko S.A., Goldberg A.V., Tuzikov S.A., Miller S.A., Rodionov E.O., Efteev L.A., Bondar L.N., Perelmuter V.M. Pulmonary histocytosis X: clinical observation of early-stage disease. Bulletin of Siberian Medicine. 2017;16(2):195-201. (In Russ.) https://doi.org/10.20538/1682-0363-2017-2-195-201
Views:
1284
Email this article 