HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL
https://doi.org/10.20538/1682-0363-2013-1-43-48
Abstract
Leucomisine model of acute hyperlipidemia in rats induced by administration of ethanol reduces the levels of free fatty acids and triacylglycerols in serum and the content of triacylglycerols in the liver of experimental animals. Introduction sesquiterpenoid leucomisine increases the activity of enzymes antiperoxidant protecti- on – glutathione peroxidase and glutathione reductase and the level of total and reduced glutathione, which prevents the activation of lipid peroxidation in the liver caused by ethanol. Lipid-lowering effect induced by the hyperlipidemia leucomisine when, like nicotinic acid, may be due to an inhibitory effect on lipolysis in adipose tissue. Along with this leucomisine has an antioxidant effect due to the activation of enzymes antiperoxidant protect and increase the redox potential of glutathione in the liver of rats.
About the Authors
E. A. Rodnova
Siberian Medical University, Tomsk
Russian Federation
Department of Pharmaceutical Technology
Russian Federation
Department of Pharmaceutical Technology
V. V. Ivanov
Siberian Medical University, Tomsk
Russian Federation
Department of Biochemistry and Molecular Biology
Russian Federation
Department of Biochemistry and Molecular Biology
S. I. Ledyukova
Siberian Medical University, Tomsk
Russian Federation
5th year student of the Faculty of Pharmacy
Russian Federation
5th year student of the Faculty of Pharmacy
V. S. Chuchalin
Siberian Medical University, Tomsk
Russian Federation
Department of Pharmaceutical Technology
Russian Federation
Department of Pharmaceutical Technology
A. V. Ratkin
Siberian Medical University, Tomsk
Russian Federation
Department of Pharmaceutical Technology
Russian Federation
Department of Pharmaceutical Technology
B. B. Rakhimova
International scientific-industrial holding "Phytochemistry ", Karaganda
Kazakhstan
Kazakhstan
I. A. Khabarov
International scientific-industrial holding "Phytochemistry ", Karaganda
Kazakhstan
Kazakhstan
S. M. Adekenov
International scientific-industrial holding "Phytochemistry ", Karaganda
Kazakhstan
Kazakhstan
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Review
For citations:
Rodnova E.A., Ivanov V.V., Ledyukova S.I., Chuchalin V.S., Ratkin A.V., Rakhimova B.B., Khabarov I.A., Adekenov S.M. HYPOLIPIDEMIC EFFECT LEUCOMISINE MODEL OF ACUTE HYPERLIPIDEMIA INDUCED BY ETHANOL. Bulletin of Siberian Medicine. 2013;12(1):43-48. (In Russ.) https://doi.org/10.20538/1682-0363-2013-1-43-48
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