The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis
https://doi.org/10.20538/1682-0363-2012-6-213-215
Abstract
With attracting contemporary molecular-genetic and immunological research methods, it has been established that blood eosinophilia under pulmonary tuberculosis is mediated by hypersecretion eotaxin. Susceptibility to the emergence of eosinophilic blood reaction under tubercular infection is associated with the allele G and homozygous genotype GG of the polymorphic region A-384G of the gene eotaxin as well as with allele С and homozygous genotype СС polymorphism T-51C of the gene ССR3.
About the Authors
K. O. Miheeva
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
Yu. V. Kolobovnikova
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
O. I. Urazova
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
V. V. Novitsky
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
O. V. Filinyuk
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
M. D. Goncharov
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
I. O. Naslednikova
Сибирский государственный медицинский университет, г. Томск
Russian Federation
Russian Federation
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Review
For citations:
Miheeva K.O., Kolobovnikova Yu.V., Urazova O.I., Novitsky V.V., Filinyuk O.V., Goncharov M.D., Naslednikova I.O. The role of polymorphism of genes eotaxin (–384) and CCR3 (–51) in formation of blood eosinophilia under pulmonary tuberculosis. Bulletin of Siberian Medicine. 2012;11(6):213-215. (In Russ.) https://doi.org/10.20538/1682-0363-2012-6-213-215
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