Association of СОМТ gene polymorphisms with Parkinson’s disease
https://doi.org/10.20538/1682-0363-2017-3-70-78
Abstract
Parkinson’s disease (PD) is one of the most serious and widespread neurodegenerative disorders. Genetic susceptibility plays a significant role in the development of PD.
The aim of our study was to investigate associations between single nucleotide polymorphisms (SNPs) of the COMT gene coding dopamine catabolism enzyme and Parkinson’s disease.
Materials and methods. In this study seven SNPs (rs4680, rs6269, rs4633, rs4818, rs769224, rs165774, rs174696) of COMT were genotyped. 232 patients with PD and 127 healthy individuals in the Siberian region of Russia were examined. Venous blood samples were drawn as a marker of PD. Statistical differences in the prevalence of alleles and genotypes between groups of patients were assessed using IBM SPSS Statistics 23.1 software.
Results. A significant association between the rs165774 polymorphism and PD was observed. Our study demonstrates that polymorphisms in the COMT gene may play an important role in the pathophysiology of Parkinson’s disease.
About the Authors
Svetlana A. Ivanova
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS);
National Research Tomsk Polytechnic University (NR TPU)
Russian Federation
DM, Professor, Head of the Molecular Genetics and Biochemistry Laboratory, Deputy Director, Mental Health Research Institute, Tomsk NRMС, RAS; Professor, Department of Ecology and Basic Safety, NR TPU, Tomsk, Russian Federation.
Russian Federation
DM, Professor, Head of the Molecular Genetics and Biochemistry Laboratory, Deputy Director, Mental Health Research Institute, Tomsk NRMС, RAS; Professor, Department of Ecology and Basic Safety, NR TPU, Tomsk, Russian Federation.
Valentina M. Alifirova
Siberian State Medical University (SSMU)
Russian Federation
DM, Professor, Head of the Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Russian Federation
DM, Professor, Head of the Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Irina A. Zhukova
Siberian State Medical University (SSMU)
Russian Federation
Associate Professor, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Russian Federation
Associate Professor, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Vladimir V. Tiguntsev
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS)
Russian Federation
Postgraduate Student, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Russian Federation
Postgraduate Student, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Ivan V. Pozhidaev
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS);
National Research Tomsk State University (NR TSU)
Russian Federation
Postgraduate Student, National Research Tomsk State University, Junior Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Russian Federation
Postgraduate Student, National Research Tomsk State University, Junior Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Diana Z. Osmanova
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS);
National Research Tomsk State University (NR TSU)
Russian Federation
Postgraduate Student, NR TSU; Junior Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Russian Federation
Postgraduate Student, NR TSU; Junior Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Olga Yu. Fedorenko
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS);
National Research Tomsk Polytechnic University (NR TPU)
Russian Federation
DM, Leading Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS; Professor, Department of Ecology and Basic Safety, NR TPU, Tomsk, Russian Federation
Russian Federation
DM, Leading Researcher, Molecular Genetics and Biochemistry Laboratory, Mental Health Research Institute, Tomsk NRMС, RAS; Professor, Department of Ecology and Basic Safety, NR TPU, Tomsk, Russian Federation
Maxim B. Freydin
Research Institute of Medical Genetics, Tomsk National Research Medical Centre (NRMC), Russian Academy of
Sciences (RAS)
Russian Federation
DBSc, Senior Researcher, Population Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Russian Federation
DBSc, Senior Researcher, Population Genetics Laboratory, Research Institute of Medical Genetics, Tomsk NRMС, RAS, Tomsk, Russian Federation.
Yulia S. Mironova
Siberian State Medical University (SSMU)
Russian Federation
Postgraduate Student, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Russian Federation
Postgraduate Student, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Natalia G. Zhukova
Siberian State Medical University (SSMU)
Russian Federation
DM, Professor, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Russian Federation
DM, Professor, Neurology and Neurosurgery Department, SSMU, Tomsk, Russian Federation.
Nikolay A. Bokhan
Mental Health Research Institute, Tomsk National Research Medical Centre (NRMC), Russian Academy of Sciences (RAS);
Siberian State Medical University (SSMU);
National Research Tomsk State University (NR TSU)
Russian Federation
DM, Professor, Academician of RAS, Director, Mental Health Research Institute, Tomsk NRMС, RAS; Head of the Department of Psychiatry, Narcology and Psychotherapy, SSMU; Professor, Department of Psychotherapy and Psychological Counseling, NR TSU, Tomsk, Russian Federation.
Russian Federation
DM, Professor, Academician of RAS, Director, Mental Health Research Institute, Tomsk NRMС, RAS; Head of the Department of Psychiatry, Narcology and Psychotherapy, SSMU; Professor, Department of Psychotherapy and Psychological Counseling, NR TSU, Tomsk, Russian Federation.
Anton J.M. Loonen
Groningen Research Institute of Pharmacy (GRIP), University of Groningen
Netherlands
MD, Professor, Groningen Research Institute of Pharmacy, University of Groningen, Netherlands.
Netherlands
MD, Professor, Groningen Research Institute of Pharmacy, University of Groningen, Netherlands.
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Review
For citations:
Ivanova S.A., Alifirova V.M., Zhukova I.A., Tiguntsev V.V., Pozhidaev I.V., Osmanova D.Z., Fedorenko O.Yu., Freydin M.B., Mironova Yu.S., Zhukova N.G., Bokhan N.A., Loonen A. Association of СОМТ gene polymorphisms with Parkinson’s disease. Bulletin of Siberian Medicine. 2017;16(3):70-78. (In Russ.) https://doi.org/10.20538/1682-0363-2017-3-70-78
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