Clinical and metabolic effects of aminophosphonate therapy in children with heart rhythm disturbances
https://doi.org/10.20538/1682-0363-2017-3-176-184
Abstract
The aim of the survey is to summarize and assess a number of studies that examined the clinical and metabolic effects of aminophosphonates, particularly dimephosphon, which possess antioxidant and membrane-stabilizing effects. This paper presents a differential effect of dimephosphon on cell membrane functional activity as well as on structural features of platelet membrane as a model of smooth muscle cell in combined therapy in children with different clinical varieties of sick sinus syndrome.
About the Authors
Olga V. Senatorova
Tyumen Cardiology Research Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
PhD, Junior Researcher, Laboratory of Epidemiology and Prevention of Cardiovascular Diseases, Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
Russian Federation
PhD, Junior Researcher, Laboratory of Epidemiology and Prevention of Cardiovascular Diseases, Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
Elena B. Khramova
Tyumen State Medical University
Russian Federation
DМ, Head of the Department of Children Diseases, Tyumen State Medical University, Tyumen, Russian Federation.
Russian Federation
DМ, Head of the Department of Children Diseases, Tyumen State Medical University, Tyumen, Russian Federation.
Vadim A. Kuznetsov
Tyumen Cardiology Research Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
DM, Professor, Honored Scientist of the Russian Federation, Director of Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
Russian Federation
DM, Professor, Honored Scientist of the Russian Federation, Director of Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
Oksana I. Sergeychik
Tyumen Cardiology Research Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation
PhD, Scientific Researcher, Laboratory of Instrumental Diagnostics, Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
Russian Federation
PhD, Scientific Researcher, Laboratory of Instrumental Diagnostics, Tyumen Cardiology Center, branch of the Tomsk National Research Medical Center of the Russian Academy of Sciences, Tyumen, Russian Federation.
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Review
For citations:
Senatorova O.V., Khramova E.B., Kuznetsov V.A., Sergeychik O.I. Clinical and metabolic effects of aminophosphonate therapy in children with heart rhythm disturbances. Bulletin of Siberian Medicine. 2017;16(3):176-184. (In Russ.) https://doi.org/10.20538/1682-0363-2017-3-176-184
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