EFFECT OF IMMUNE CELLS ON THE BEHAVIORAL ACTIVITY LEVEL OF MICE (СВАхC57BI/6)F1 DURING ONTOGENESIS
https://doi.org/10.20538/1682-0363-2015-1-5-11
Abstract
The features of forming of the orientation and exploratory behavior level (OEB) was established on sexually immature animals – mice (CBAxC57/Bl)F1, which underwent triple transplantation of splenocytes from adult syngeneic animals with a certain level of OEB during ontogenesis. Obtained data testifies an increase the part of passive animals in recipients group receiving splenocytes from low-level in behavior donors and an increase the part of animals with average level of OEB in recipients group receiving cells from donors with high OEB level and immature control group. The associations of recipients behavioral activity level with structural and functional features of donor cells was revealed: a relative increase in the OEB level under splenocytes transfer from donors with activated monocyte-macrophage link of immune system and a supression of OEB – from donors with activated T-cells.
About the Authors
O. S. Anikeeva
Research Institute of Fundamental and Clinical Immunology, Novosibirsk
Russian Federation
Anikeeva Olga S.
Russian Federation
Anikeeva Olga S.
T. Ya. Abramova
Research Institute of Fundamental and Clinical Immunology, Novosibirsk
Russian Federation
Abramova Tatyana Ya.
Russian Federation
Abramova Tatyana Ya.
V. A. Kozlov
Research Institute of Fundamental and Clinical Immunology, Novosibirsk
Russian Federation
Kozlov Vladimir A.
Russian Federation
Kozlov Vladimir A.
References
1. Abramov V.V. Vzaimodeistvie immunnoy i nervnoy sistem [Interaction between immune and nervous systems]. Novosibirsk, Science Publ., 1988. 165 p. (in Russian).
2. Abramova T.Ya. Vzaimodeystvie nervnoy i immunnoy sistem v norme i pri immunnopatologicheskih processah [The interaction of the nervous and immune systems in health and immunopathologically processes]. Fundamental'nye problemy nejronauk [Fundamental problems of neuroscience]. Moscow, 2014. Pp. 6–15. (in Russian).
3. Abramov V.V., Abramova T.Ya., Yegorov D.N. et al. Vysshaya nervnaya dejatel'nost' i immunitet [Higher nervous activity and immunity]. Novosibirsk, RAMS SB Publ., 2001. 123 p. (in Russian).
4. Zakharova L.A. Plastichnost' neyroendokrinnoy i immunnoy sistem v rannem razvitii [Plasticity of neuroendocrine and immune systems in early ontogenezis]. Izvestiya RAN – News of RAS, 2014, no. 5, pp. 437–447 (in Russian).
5. Dantzer R. How do cytikines say hello to the brain? Neural versus humoral mediation. Eur. Cytokine Netw., 1994, vol. 5, no. 3, pp. 271–273.
6. Rotenberg V.S. Search activity concept: relationship between behavior, health and brain functions. Activitas Nervosa Superior, 2009, 51 (1), pp. 12–44.
7. Gaufo G., Diamond M.C. Prolactin increases CD4/CD8 cell in ratio in thymus-fgrafted congenitally athymic nude mice. Proc. Nat. Acad. Sci. USA, 1996, vol. 93, no. 9, pp. 4165–4169.
8. Kaaijk P., Pals S.T., Morsink F. et al. Differential expression of CD44 splice variants in the normal human CNS. J. of Neuroimmunol., 1997, vol. 73, no. 1, 2, pp. 70–76.
9. Abramova T.Ya., Poveshchenko A.F. et al. Funkcional'naya asimmetriya immunnoy, krovetvornoy i neyroendokrinnoy sistem. Rukovodstvo po funkcional'noy mezhpolusharnoy asimmetrii [Functional asymmetry of the immune, hematopoietic and neuroendocrine systems. Manual functional hemispheric asymmetry]. Moscow, Scientific World Publ., 2009. Pp. 274–302 (in Russian).
10. Markova Ye.V., Knyazheva M.A., Kozlov V.A. Kletochnye mehanizmy neyroimmunnyh vzaimodejstviy v reguljacii orientirovochno-issledovatel'skogo povedeniya [Cellular mechanisms of neuroimmune interactions in the regulation of approximately research behavior]. Sibirskiy vestnik psihiatrii i narkologii – Siberian Gerald of Psychiatry and Addiction Psychiatry, 2013, no. 1, pp. 49–52 (in Russian).
11. Markova Ye.V., Abramov V.V., Kozlov V.А. Reguljaciya orientirovochno-issledovatel'skogo povedeniya u zhivotnyh putem transplantacii immunokompetentnyh kletok [Regulation of the behavior parameters behavior at animals by transplantation of immune cells]. Uspehi sovremennoy biologii – Biology Bulletin Reviews, 2009, vol. 129, no. 4, pp. 348–355(in Russian).
12. Markova Ye.V., Knyazheva M.A., Ryumina T.V., Kozlov V.А. Osobennosti funkcionirovaniya kletok immunnoy sistemy u osobey s agressivno i depressivno-podobnym tipami povedeniya [Immune cells functioning features in individuals with aggressiveand depressive-like behaviors]. V mire nauchnyh otkrytiy – In the World of Scientific Discoveries, 2014, no. 8 (56), pp. 131–148 (in Russian).
13. Buresh Ya., Bureshova O., Huston D.P. Metodiki i osnovnye eksperimenty po izucheniyu mozga i povedeniya [Techniques and basic experiments to study the brain and behavior]. Moscow, 1991.
14. Kudayeva O.T., Gavrilova Ye.D., Kolesnikova O.P., Kozlov V.A. Formirovanie immunnoy pamyati pri stimulyacii pervichnogo gumoral'nogo otveta [The formation of immune memory under the stimulation of primary antibody response]. Rossiyskiy immunologicheskiy zhurnal – Russian Journal of Immunology, 2010, vol. 4 (13), no. 3, pp. 237–247 (in Russian).
15. Dusbery D. Povedenie zhivotnyh: sravnitel'nye aspekty [Animal Behaviour: Comparative aspects]. Moscow, World Publ., 1981. 480 p. (in Russian).
16. Goodkin K., Visser A.P. Psychoneuroimmunology: Stress, Mental Disorders, and Health. American Psychiatric Press, 2000.
17. Tsimbalyuk V.I., Pichkur L.D., Rudenko V.A., Lisyanyj N.I., Pichkur O.V. Immunologicheskie aspekty transplantacii embrional'noy nervnoy tkani [Immunological aspects of transplantation of embryonic nerve tissue]. Voprosy neyrohirurgii – Journal of Neurosurgery, 2001, no. 3 (in Russian).
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For citations:
Anikeeva O.S., Abramova T.Ya., Kozlov V.A. EFFECT OF IMMUNE CELLS ON THE BEHAVIORAL ACTIVITY LEVEL OF MICE (СВАхC57BI/6)F1 DURING ONTOGENESIS. Bulletin of Siberian Medicine. 2015;14(1):5-11. (In Russ.) https://doi.org/10.20538/1682-0363-2015-1-5-11
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