INFLUENCE OF MAGNETOMICELLS BASED ON IRON NANOPARTICLES COATED BY CARBON ON STRUCTURE OF RAT LIVER
https://doi.org/10.20538/1682-0363-2015-2-5-11
Abstract
In this paper we study the effect of a single intravenous injection of suspension of magnitomitsell based on iron nanoparticles modified with carbon on the structure of the rat liver. Histological examination revealed the hemodynamic disturbances in the stroma of the organ and degenerative changes of hepatocytes from 1 to 40 days of the experiment. Perls histochemical reaction demonstrated the accumulation of modified iron nanoparticles in cells of the mononuclear phagocyte system of the liver. Number of Perlspositive macrophages decreased during the experiment from 1 to 40 per day.
About the Authors
G. Yu. Vasyukov
Siberian State Medical University, Tomsk; Institute of Complex Problems of Cardio-Vascular Diseases, Kemerovo
Russian Federation
Vasyukov Georgy Yu.
Russian Federation
Vasyukov Georgy Yu.
I. V. Milto
Siberian State Medical University, Tomsk; National Research Tomsk Polytechnic University, Tomsk
Russian Federation
Milto Ivan V.
Russian Federation
Milto Ivan V.
I. V. Sukhodolo
Siberian State Medical University, Tomsk
Russian Federation
Sukhodolo Irina V.
Russian Federation
Sukhodolo Irina V.
I. V. Mitrofanova
Siberian State Medical University, Tomsk
Russian Federation
Mitrofanova Irina V.
Russian Federation
Mitrofanova Irina V.
References
1. Gleiter H. Nanocrystalline Materials. Adv. Struct. and Func. Mat., 1991, pp. 1–37.
2. Gubin S.P., Koshkarov Yu.A., Khomutov G.B., Yurkov G.Yu. Magnitnye nanochasticy: metody polychenia, struktura i svoijstva [Magnetic nanoparticals: methods of obtaining, structure and properties]. Uspekhi khimii – Russian Chemical Reviews, 2005, no. 74, pp. 539–574.
3. Mitrofanova I.V., Milto I.V., Sukhodolo I.V., Vasyukov G.Yu. Vozmozhnosti biomedicinskogo primenenia uglerodnih nanotrubok [Opportunities of biomedical applications of carbon nanotubes]. Bulleten sibirskoi mediciny – Bulletin of Siberian Medicine, 2014, vol. 13, no. 1, pp. 135–144.
4. Kuznetsov A.A., Shlyakhtin O.A., Brusentsov N.A., Kuznetsov O.A. “Smart” mediators for self-controlled inductive heating. Eur. Cells Mater., 2002, vol. 3, no. 2, pp. 75–77.
5. Nikiforov V.N., Filinova E.Yu. Biomedical applications of the magnetic nanoparticles. Wiley, 2009, pp. 393–454.
6. Kuznetsov V.D., Brusnetsova T.N., Brusnetsov N.A. et al. Temperaturnye zavisimosti namagnichennosti preparatov dlya magnitnoyi gipertermii [The temperature dependences of drugs magnetization for magnetic hyperthermia]. Izvestiya vuzov, seriya Fizika – Russian Physics Journal, 2005, vol. 48, no. 2, pp. 47–52.
7. Berry C., Curtis A. Functionalisation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys., 2003, vol. 36, no. 13, pp. 30–38.
8. Shen L., Laibinis P.E., Hatton T.A. Bilayer Surfactant Stabilized Magnetic Fluids: Synthesis and Interactions at Interfaces. Langmuir, 1999, vol. 15, no. 2, pp. 447–453.
9. Borm P., Robbins D., Haubold S. et al. The potential risks of nanomaterials. Particle and fibre toxicology, 2006, vol. 3, pp. 1–36.
10. Brusnetsov N.A., Gogosov V.V., Lukashevich M.V. Fizicheskie i khimicheskie kriterii ferromagnetikov dlya biomedicinskih celey [Physical and chemical criteria of ferromagnets for biomedical applications]. Khimicheskii Farmacevticheskii Zhurnal – Pharmaceutical Chemistry Journal, 1996, no. 10, pp. 48–53.
11. Vasukov G.U., Mitrofanova I.V., Ivanova V.V., Prokopieva V.D. Poverhnostno modificirovannie magnitnie nanochastici dlia medico-biologicheskogo primeneniia [Surface modified magnetic nanoparticles for biomedical application]. Bulleten sibirskoi mediciny – Bulletin of Siberian Medicine, 2014, vol. 13, no. 6, pp. 33–40.
12. Milto I.V., Mikhailov G.A., Ratkin A.V., Magaeva A.A. Vliyanie nanorazmernyh chastic na morfologiu vnutrennih organov myshi pri vnutrivennom vvedenii rastvora nanoporoshka Fe3O4 [Effect of nanoscale particles on morphology of internal organs of mouse by intravenous injection of solution of nanopowder Fe3O4]. Bulleten sibirskoi mediciny – Bulletin of Siberian Medicine, 2008, vol. 7, no. 1, pp. 32–36.
13. Gaucher G., Dufresne M.H., Sant V.P. et al. Block copolymer micelles: preparation, characterization and application in drug delivery. J. Control Release, 2005, vol. 109, no. 1, pp. 169–188.
14. Fahmy T.M., Fong P.M., Park J. et al. Nanosystems for simultaneous imaging and drug delivery to T cells. AAPS J, 2007, vol. 9, no. 4, pp. E171–E180.
15. Galakhov V.R., Shkvarin A.S., Semenova A.S. et al. Characterization of carbon-encapsulated nickel and iron nanoparticles by means of X-ray absorption and photoelectron spectroscopy. J. Phys. Chem., 2010, vol. 114, pp. 22413–22416.
16. Antipov S.A., Feduschak T.A., Kokorev O.V., Gereng E.A. Protivoopukholevye effekty in vitro i in vivo lipidnyh kompositov cisplastina i nanochastic ferromagnetika vuglerodnoy obolochke [In vitro and in vivo antitumor effects of cisplatin lipid components and ferromagnetic nanoparticles in carbon capsule]. Bulleten sibirskoi mediciny – Bulletin of Siberian Medicine, 2010, vol. 9, no. 1, pp. 9–17.
17. Milto I.V., Suhodolo I.V. Struktura pecheni, legkogo, pochek, serdca i selezenki posle mnogokratnogo vnutrivennogo vvedeniya suspenzii nanorazmernyh chastic magnetite [The structure of the liver, lung, kidney, heart and spleen of rats after multiple intravenous injection of a suspension of nanoparticles of magnetite]. Vestnik RAMN, 2012, no. 3, pp. 75–79.
Review
For citations:
Vasyukov G.Yu., Milto I.V., Sukhodolo I.V., Mitrofanova I.V. INFLUENCE OF MAGNETOMICELLS BASED ON IRON NANOPARTICLES COATED BY CARBON ON STRUCTURE OF RAT LIVER. Bulletin of Siberian Medicine. 2015;14(2):5-11. (In Russ.) https://doi.org/10.20538/1682-0363-2015-2-5-11
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