Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas
https://doi.org/10.20538/1682-0363-2011-1-55-58
Abstract
The concentrations of matrix metalloproteinases (MMP-2, -3, -9) and their tissue inhibitors (TIMP-1, -2) were studied in blood serum of 193 patients with squamous cell head and neck carcinoma (SCHNC) and in 38 healthy donors using immunoenzymatic assay. The decreased MMP-3 and TIMP-1, -2 levels were found in patients with oral cavity tumors as compared to patients with laryngeal cancer. The serum MMP-9 and TIMP-1 levels were significantly higher in head and neck cancer patients than in healthy subjects. High TIMP-1 and MMP-9 levels in blood serum of patients with SCHNC should be greatly attended for detection of their predictive and prognostic significances.
About the Authors
Ye. V. Klisho
НИИ онкологии СО РАМН
Russian Federation
Russian Federation
I. V. Kondakova
НИИ онкологии СО РАМН
Russian Federation
Russian Federation
Ye. L. Choynzonov
НИИ онкологии СО РАМН;
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
O. V. Cheremisina
НИИ онкологии СО РАМН
Russian Federation
Russian Federation
D. A. Shishkin
НИИ онкологии СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Klisho Ye.V., Kondakova I.V., Choynzonov Ye.L., Cheremisina O.V., Shishkin D.A. Matrix metalloproteinase system in blood serum in patients with squamous cell head and neck carcinomas. Bulletin of Siberian Medicine. 2011;10(1):55-58. (In Russ.) https://doi.org/10.20538/1682-0363-2011-1-55-58
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