ETIOLOGY AND PATHOGENESIS OF RETINAL VEIN OCCLUSION: THE ACTUAL STATE OF A PROBLEM
https://doi.org/10.20538/1682-0363-2015-2-82-90
Abstract
The review presents the actual questions of the etiopathogenesis of central retinal vein occlusion and its branches. It was found that predictors of disease is a pathology of haemostasis, including asymptomatic gene mutations of coagulation factors and platelet receptors, chronic viral infections, rheumatological and oncological diseases, hypertension, metabolic disorders, smoking, physical inactivity, inflammatory diseases of the retinal and optic nerve, congenital and acquired abnormalities of retinal vascular, glaucoma.
The article also focused on the reasons for the formation of a blood clot. This is damage to the vascular wall, slowing the speed of blood flow in the vessel, hypercoagulation and hypofibrinolysis. Prevailing theories of the pathogenesis of retinal vein occlusion are analyzed. This is mechanical and theory “coag- ulopathy” whose arguments and counterarguments are discussed in detail. In addition, patients with reti- nal vein occlusion are needed in a multidisciplinary approach to the treatment of this disease. It is to im- prove the clinical and functional results of therapy and prevent the case of retrombosis.
About the Authors
A. A. Krylova
Siberian State Medical University, Tomsk
Russian Federation
Krylova Anna A.
Russian Federation
Krylova Anna A.
I. V. Zapuskalov
Siberian State Medical University, Tomsk
Russian Federation
Zapuskalov Igor V.
Russian Federation
Zapuskalov Igor V.
O. I. Krivosheina
Siberian State Medical University, Tomsk
Russian Federation
Krivosheina Olga I.
Russian Federation
Krivosheina Olga I.
References
1. The World Health Report 2013: Research for universal health coverage. World Health Organization. Geneva, WHO Press, 2013. 146 p.
2. Tultseva S.N., Astakhov Yu.S. Okklyuzii ven setchatki (etiologiya, patogenez, klinika, diagnostika, lechenie) [Reti- nal vein occlusion (etiology, pathogenesis, clinical features, diagnosis, treatment)]. St. Petersburg, H-L Publ., 2010. 112 p.
3. Tankovskiy V.E. Tromboz ven setchatki [Retinal vein thrombosis]. Moscow, Voenizdat Publ., 2000. 263 p.
4. Rykov S.A., Suk S.A., Romanova T.A., Venediktova O.A. Rasprostranenie tromboza ven setchatki v structure lazernyh vmeshatelstv na zadnem otrezke glaza [Spread retinal vein thrombosis in the structure of the laser interventions on the posterior segment of the eye]. Tavricheskiy medikobiologicheskiy vestnik, 2012, vol. 15, no. 3, pt. 3(59), pp. 164–169.
5. Libman Ye.S., Schahova Ye.V. Sostoyanie i dinamika slepoty i invalidnosti v sledstvie patologii organa zreniya v Rossii [State and dynamics ofblindness and visualdisabilitydue to the pathology of the visionin Russia]. Aktualnye voprosy oftalmologii, 2007, no. 2, pp. 12–19.
6. Kanski J.J. Retinal venous occlusive disease. Clinical oph- thalmology: a systematic approach, 6th ed. Edinburg, Lon- don, MD: Butterworth-Heinemann ELSEVIER, 2007. Pp. 584–590.
7. Cugati S., Wang J. J. Knudtson M. D Retinal vein occlusion and vascular mortality. Ophthalmology, 2007, vol. 114, no. 3, pp. 520–524.
8. Rogers S.L., McIntosh R.L., Cheung N. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Oph- thalmology, 2010, vol. 117, no. 2, pp. 313–319.
9. Klein R., Klein B.E., Moss S.E., Meuer S.M. The epidemi- ology of retinal vein occlusion: The Beaver Dam Eye Study. Am. Acad. of Ophthalmol. Retina and vitreous: Basic and clinical science course, Sec. 12. Singapore, 2007–2008. Pp. 136–145.
10. Cugati S, Wang J.J., Rochtchina E. Ten year incidence of retinal vein occlusion in an older population: The blue mountains eye study. Arch. Ophthalmol., 2006, vol. 124, pp. 726–732.
11. Klein R., Moss S.E., Meuer S.M., Klein B.E. The 15 year cu- mulative incidence of retinal vein occlusion: The beaver dam eye study. Arch. Ophthalmol., 2008, vol. 126, pp. 513–518.
12. Rogers S.L., McIntosh R.L., Lim L. Natural history of branch retinal vein occlusion: an evidence-based systematic review. Ophthalmology, 2010, vol. 117, no. 6, pp. 1094–1101.
13. Hayreh S.S. Prevalent misconceptions about acute retinal vascular occlusive disorders. Prog. Retin. Eye Res., 2005, vol. 24, no. 4, pp. 493–519.
14. Hayreh S.S., Zimmerman M.B., Podhajsky P. Incidene of various types of retinal vein occlusion and their recurrent and demographic characteristics. Am. J. Ophthalmol., 1994, vol. 117, no. 4, pp. 429–441.
15. Takizawa Y., Hayashi S., Fujimaki T. Central retinal vein occlusion caused by human herpesvirus 6. J. Pediatr. Ophthalmol. Strabismu, 2006, vol. 43, no. 3, pp. 176–178.
16. Wu O., Robertson L., Langhorne P. et al. Oral contraceptives, hormone replacement therapy, thrombophilias and risk of venous thromboembolism: a systematic review. Thromb. Haemost., 2005, Jul., vol. 94, no. 1, pp. 17–25.
17. Recommendations from the EGAPP Working Group: routine testing for FactorV Leiden (R506Q) and prothrombin (20210G>A) mutations in adults with a history of idiopathic venous thromboembolism and their adult family members. Genet. Med., 2011, Jan., vol. 13, no. 1, pp. 67–76.
18. Thapa R., Paudyal G. Central retinal vein occlusion in young women: Rare cases with oral contraceptive pills as a risk fac- tor. Nepal Med. Coll. J., 2009., vol. 11, pp. 209–211.
19. Rohina S., Vineet V.M., Somesh V.A. Oral contraceptive pills: A risk factor for retinal vascular occlusion in in vitro fertilization patients. J. of Human Reproductive Science, 2013, Jan–Mar., vol. 6, no. 1, pp. 79–81.
20. Klein R., Klein B.E., Lee K.E. et al. Changes in visual acuity in a population over a 15 year period: the Beaver Dam Eye Study. Am. J. Ophthalmol., 2006, vol. 142, no. 4, pp. 539–549.
21. Stefansson E. The therapeutic effects of retinal laser treat- ment and vitrectomy: a theory based on oxygen and vascular physiology. Acta Ophthalmol. Scand., 2001, vol. 79, pp. 435–440.
22. Browning D.J. Retinal vein occlusion. New York, Springer, 2012. 193 p.
23. Gluek C.J., Bell H., Vadlamani L. et al. Heritable thrombo- philia and hypofibrinolysis. Possible causes of retinal vein occlusion. Arch. Ophthalmol., 1999, vol. 117, pp. 43–49.
24. Glueck C.J., Wang P., Bell H. et al. Associations of throm- bophilia, hypofibrinolysis, and retinal vein occlusion. Clin. Appl. Thromb. Hemost., 2005, vol. 11, pp. 375–389.
25. Urakova N.A. Kompleksnoe lechenie vospalitelnyh okklyuzy ven setchatki i ego vliyanie na komponenty gemostaza: avtoref. dis. kand. med. nauk [Comprehensive treatment of inflammatory retinal vein occlusion and its effect on components of hemo- stasis. Diss. Cand. med. sci.]. Moscow, 2013. 24 p.
26. O’Mahoney P.R., Wong D.T., Ray J.G. Retinal vein occlusion and traditional risk factors for atherosclerosis. Arch. Ophthalmol., 2008, vol. 126, pp. 692–699.
27. Tultseva S.N. Gipergomotsisteinemiya – osnovnoy factor riska razvitiya ishemicheskogotrombozavensetchatki [Hyperhomocysteinemia – a major risk factor for ischemic reti- nal vein thrombosis]. Meditsinskie nauki, 2008, no. 4, pp. 8–16.
28. Lim L.L., Cheung N., Wang J.J. et al. Prevalence and risk factors of retinal vein occlusion in an Asian population. Br. J. Ophthalmol., 2008, vol. 92, pp. 1316–1319.
29. Colucciello M. Retinal vascular disease in hypertension. Risk factor modification optimizes vision outcomes. Post- grad. Med. J., 2005, vol. 117, no. 6, pp. 33–38, 41–42.
30. Shrestha R.K., Shrestha J.K., Koirala S., Shah D.N. Association of systemic diseases with retinal vein occlusive disease. JNMA J. Nepal Med. Assoc., 2006, vol. 45, pp. 244–248.
31. Williamson T.H. Central retinal vein occlusion: What's the story? Br. J. Ophthalmol., 1997, vol. 81, no. 9, pp. 698–704.
32. Hayreh S.S., Zimmerman B., Beri M. Intraocular pressure abnormalities associated with central and hemi-central retinal vein occlusion. Ophthalmology, 2004, vol. 111, no. 3, pp. 133–141.
33. Simons B.D., Brucker A.J. Branch retinal vein occlusion: axial length and other risk factors. Retina, 1997, vol. 17, no. 3, pp. 191–195.
34. Mehdizadeh M., Ghassemifar V., Ashraf H., Mehryar M. Relationship between retinal vein occlusion and axial length of the eye. Asian J. Ophthalmol., 2005, vol. 7, no. 4, pp. 146–148.
35. Zapuskalov I.V., Krivosheina O.I., Khoroshih Yu.I. Biomehanika “perifericheskogo serdtsa” v tkanyah glaza [Biomechanics “peripheral heart” in the tissues of the eye]. Tomsk, Ivan Fedorov Publ., 2013. 140 p.
36. Yablitsev I.F. Narushenie mestnogo krovoobrascheniya [Vi- olation of local blood circulation]. Rossiyskoe obschestvo patologoanatomov, 2005, no. 58, pp. 23–25.
37. Gadzhiyev R.V. O patogeneze diabeticheskoy retinopatii i tromboz tsentralnoy veny setchatki [On the pathogenesisof diabetic retinopathyand central retinal vein occlusion]. Baku, Poligraphic production Publ., 2011. 71 p.
38. Astakhov Yu.S., Petrishchev N.N., Tultseva S.N. Tromboz ven setchatki: etiologiya patogenez, klinika, diagnostika, lechenie: posobie dlya vrachey [Retinal vein thrombosis: etiology, pathogenesis, clinical features, diagnosis and treatment. Manual for physicians]. St. Petersburg, SPbGMUB Publ., 2005. 60 p.
39. Wiek J., Schade M., Wiederholt M. Haemorheological changes in patients with retinal vein occlusion after isovolaemichaemodilution. Br. J. Ophthalmol., 1990, vol. 74, no. 11, pp. 665–669.
40. Petrishchev N.N., Vasina L.V. Tipovye formy disfunktsii endoteliya [Typical forms of endothelial dysfunction]. Kliniko-laboratornyy konsilium, 2007, no. 18, pp. 31–35.
41. Salvarani C., Casali B., Farnetti E. et al. PIA1/A2 polymor- phism of the platelet glycoprotein receptor IIIA and risk of cranial ischemic complications in giant cell arteritis. Arthritis & Rheumatism, 2007, Oct., vol. 56, no. 10, pp. 3502–3508.
42. Gori A.M., Marcucci R., Fatini C. et al. Impaired fibrinolysis in retinal vein occlusion: a role determinants of PAI-I levels. Thromb. Hemost., 2004, vol. 92, pp. 54–60.
43. Ehlers J.P., Fekrat S. Retinal vein occlusion: beyond the acute event. Surv. Ophthalmol., 2011, Jul–Aug., vol. 56, no. 4, pp. 281–299.
44. Quinlan P.M., Elman M.J., Bhatt A.K. et al. The natural course of central retinal vein occlusion. Am. J. Ophthalmol., 1990, vol. 110, no. 4, pp. 118–123.
45. Duker J.S., Brown G.C. Anterior location of the crossing ar- tery in branch retinal vein obstruction. Arch. Ophthalmol., 1989, vol. 107, no. 7, pp. 998–1000.
46. Williamson T.H. A “throttle” mechanism in the central retinal vein in the region of the lamina cribrosa. Br. J. Ophthalmol., 2007, vol. 91, no. 12, pp. 1190–1193.
47. Hamid S., Mirza S.A., Shokh I. Anatomic pattern of arteriovenous crossings in branch retinal vein occlusion. J. Pak. Med. Assoc., 2008, vol. 58, no. 5, pp. 233–236.
48. Garcia-Arumi J., Boixadera A. Radial Optic Neurotomy for Management of Hemicentral Retinal Vein Occlusion. Arch. Ophthalmol., 2006, vol. 124, no. 5, pp. 690–695.
49. Nomoto H., Shiraga F., Yamaji H. Evaluation of radial optic neurotomy for central retinalvein occlusionbyindocyaninegreenvideoangiographyand image analysis. Am. J. Ophthalmol., 2004, vol. 138, no. 4, pp. 612–619.
50. Spaide R.F., Klancnik J.M., Gross N.E. Retinal choroidal collateral circulation afterradial optic neurotomy correlated with the lessening of macular edema. Retina, 2004, vol. 24, no. 3, pp. 356–359.
51. Garcia-Arumi J., Martinez-Castillo V., Boixadera A. et al. Management of macular oedema in branch retinal vein oc- clusion with sheathotomy and recombinant tissue plasminogen activator. Retina, 2004, vol. 24, no. 4, pp. 530–540.
52. Rodanant N., Thoongsuwan S. Sheathotomy without separa- tion of venule overlying arteriole at occlusion site in uncommon branch retinal vein occlusion. J. Med. Assoc. Thai., 2005, vol. 88, suppl. 9, pp. 143–150.
53. Hayreh S.S. Radial optic neurotomy for nonischemic central retinal vein occlusion. Arch. Ophthalmol., 2004, vol. 122, no. 10, pp. 1572–1573.
54. Frangieh G.T., Green W.R., Barraquer-Somers E., Finkelstein D. Histopathologic study of nine branch retinal vein occlusion. Arch. Ophthalmol., 1982, vol. 100, no. 7, pp. 1132–1140.
55. Zapuskalov I.V., Krivosheina O.I., Krylova A.A. Issledovanie “massazha” retinalnyh sosudov kak vozmozhnogo sposoba lecheniya tromboza ven setchatki [A study "massage" retinal vesselsasa possible way oftreatingretinal veinocclusion]. Sovremennye tehnologii diagnostiki i lecheniya zabolevaniy organa zreniya: materi- ally Yubileynoy naucno-prakicheskoi konferentsii, posvyaschennoy 20-letiyu kursa oftalmologii FPK i PPS SibGMU [The vodern technologies of diagnosis and treat- ment of eye diseases: Proceedings of the Jubilee scientific and practical conference dedicated to the 20th anniversary of the course ophthalmology FT and RS SSMU]. Tomsk, 2014. Pp. 20–23.
56. Glacet-Bernard A., Coscas G., Chabanel A. et al. Prognostic factors for retinal vein occlusion: prospective study of 175 cases. Ophthalmology, 1996, vol. 103, pp. 551–560.
57. Pearse A.K., Srinivas R.S. Retinal vein occlusion and macu- lar edema — critical evaluation of the clinical value of ranibizumab. Clin. Ophthalmol., 2011, vol. 5, pp. 771–781.
58. Fine B.S., Brucker A.J. Macular edema and cystoid macular edema. Am. J.Ophthalmol., 1981, vol. 92, no. 4, pp. 466–481.
59. Hayreh S.S., Zimmerman M.B. Ocular neovascularization associated with central and hemicentral retinal vein occlusion. Retina, 2012, Sep., vol. 32, no. 8, pp. 1553–1565.
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For citations:
Krylova A.A., Zapuskalov I.V., Krivosheina O.I. ETIOLOGY AND PATHOGENESIS OF RETINAL VEIN OCCLUSION: THE ACTUAL STATE OF A PROBLEM. Bulletin of Siberian Medicine. 2015;14(2):82-90. (In Russ.) https://doi.org/10.20538/1682-0363-2015-2-82-90
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