The regulation mechanisms of contractile activity of smooth muscle cells: reactive oxygen species role
https://doi.org/10.20538/1682-0363-2011-3-30-36
Abstract
The effect of modulation of hydrogen peroxide, nitric oxide and hydrogen sulfide on contractile reactions of smooth muscle cells caused by depolarization, phenylephrine and solutions with altered osmolarity has been investigated by the mechanographical method. The new data of the fundamental nature of the role of reactive oxygen species in the operation of calcium and cGMP-mediated intracellular signaling systems, as well as in volume-dependent regulation of smooth muscle contraction.
About the Authors
S. V. Gusakova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. B. Baskakov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. V. Kovalev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
A. S. Zheludeva
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
L. V. Smagly
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. A. Medvedev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
S. N. Orlov
Научно-исследовательский центр Университета г. Монреаль
Canada
Canada
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Review
For citations:
Gusakova S.V., Baskakov M.B., Kovalev I.V., Zheludeva A.S., Smagly L.V., Medvedev M.A., Orlov S.N. The regulation mechanisms of contractile activity of smooth muscle cells: reactive oxygen species role. Bulletin of Siberian Medicine. 2011;10(3):30-36. (In Russ.) https://doi.org/10.20538/1682-0363-2011-3-30-36
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