Effect of alloxan on glutathione system and oxidative protein modification in adipocytes of rats at experimental diabetes
https://doi.org/10.20538/1682-0363-2011-3-44-47
Abstract
There was carried out a research of the development of oxidative stress, the condition of glutathione dependant system of antioxidant protection in adipocytes of epididymal adipose tissue of rats when injecting alloxan. The development of oxidative stress in adipocytes was characterized by the increase of lipids hydroperoxide concentration, products reacting with thiobarbituric acid, and the increase of carbonylderived protein. Redox-condition in adipocytes was considerably changing that was specified by the decrease of the content of the reduced form of glutathione and tendency to the increase of glutathione disulfide content, decrease of ratio between reduced and oxidized forms of threepeptide. Damage of protein molecule at oxidative stress may lead to the abnormality of transduction of insulinic signal and appearance of insulin resistance in adipose tissue.
About the Authors
V. V. Ivanov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
Ye. V. Shakhristova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
Ye. A. Stepovaya
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. V. Novitsky
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Ivanov V.V., Shakhristova Ye.V., Stepovaya Ye.A., Novitsky V.V. Effect of alloxan on glutathione system and oxidative protein modification in adipocytes of rats at experimental diabetes. Bulletin of Siberian Medicine. 2011;10(3):44-47. (In Russ.) https://doi.org/10.20538/1682-0363-2011-3-44-47
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