Histochemical research of cells functionally leading tissue liver and kidneys of rats after intravenous application of nanoparticles magnetite
https://doi.org/10.20538/1682-0363-2018-3-48-53
Abstract
After unitary and repeated intravenous application magnetite is shown their distribution in organism of a rat by method of magnetic resonance imaging. Accumulation of particles in a liver and a spleen of animals is shown. We studied intracellular activity main enzymes of hepatocyte and nephrocyte rats in various periods after intravenous application of nanoparticles magnetite by histochemical method. Intravenous application of magnetite is accompanied change of energetic and plastic metabolism of studied cells.
About the Authors
I. V. MiltoRussian Federation
I. V. Sukhodolo
Russian Federation
T. K. Klimentiyeva
Russian Federation
N. M. Shevtsova
Russian Federation
References
1. Карр Я. Макрофаги: обзор ультраструктуры и функции: пер. с англ. М.: Медицина, 1978. 189 с.
2. Ллойда З., Госсрау Р., Шиблер Т. Гистохимия ферментов (лабораторные методы): пер. с англ. М.: Мир, 1982. 272 с.
3. Мильто И.В., Дзюман А.Н. Структура печени, легкого и почек крыс при внутривенном введении магнитолипосом // Морфология. 2009. № 3. С. 63—66.
4. Найден Е.П., Журавлёв В.А., Итин В.И. Структура и магнитные свойства наноразмерных порошков простых ферритов, полученных методом механохимического синтеза // Известия вузов. Физика. 2006. № 9. С. 40—44.
5. Dixon M., Needham D.M. Biochemical research on chemical warfare agents // Nature. 1946. V. 158. Р. 432—438.
6. Dobson G. Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery // Gene Therapy. 2006. V. 13. P. 283—287.
7. Gu H., Xu K., Xu C. et al. Biofunctional magnetic nanoparticles for DNA protein separation and pathogen detection // J. of the American chemical society. 2006. V. 14. P. 941—949.
8. Koneracka M., Kopcansky P., Antalik M. et al. Immobilization of proteins and enzymes to fine magnetic particles // J. of Magnetism and Magnetic Materials. 1999. V. 201. P. 427—430.
9. Martina M.S., Fortin J.P., Menager C. et al. Generation of superparamagnetic liposomes revealed as highly efficient MRI contrast agents for in vivo imaging // J. Am. Chem. Soc. 2005. V. 127. P. 10676—10685.
10. Nishimori H., Kondoh M., Isoda K. et al. Silica nanoparticles as hepatotoxicants // Eur. J. of Pharmaceutics and Biopharmaceutics. 2009. V. 72. Р. 496—501.
11. Pankhurst Q.A., Connolly J., Jones S.K. et al. Applications of magnetic nanoparticles in biomedicine // J. Phys. D. Appl. Phys. 2003. V. 36. P. 167—181.
12. Yang Z.M., Yang Z.M., Xu K.M., Guo Z.F. et al. Intracellular enzymatic formation of nanofibers results in hydrogelation and regulated cell death // Advanced Materials. 2007. V. 17. Р. 3152—3156.
Review
For citations:
Milto I.V., Sukhodolo I.V., Klimentiyeva T.K., Shevtsova N.M. Histochemical research of cells functionally leading tissue liver and kidneys of rats after intravenous application of nanoparticles magnetite. Bulletin of Siberian Medicine. 2011;10(3):48-53. (In Russ.) https://doi.org/10.20538/1682-0363-2018-3-48-53