Dynamics of clinical-laboratory markers of cholestasis on the ursosan therapy in patients with organic abnormalities of the bile-excreting tracts drainage function

Abstract

Study of the ursosan therapy influence on the efficiency of the surgical resolution of cholestasis in the early postoperative period on the bile-excreting tracts. 19 healthy people and 24 patients with organic abnormalities of the drainage function of the bile ducts are examined. The analysis of the clinical, laboratory and instrumental criteria of cholestasis is carried out in the tested groups before and after ursosan’s therapy and the surgical treatment. Ursosan’s prescription leads to 3 times increase of cases of full regression of clinicolaboratory markers of cholestasis during the first week of the surgery on the bile ducts. The ursosan’s therapy should be prolonged more than 8 days after operative restoration of the bile passage on the bile ducts considering high level of lithogenic factors of C bile on these patients as compared to healthy people. The criteria of the completed ursosan’s therapy can be the normalization of the conjugated bilirubin level in the serum and or relief of slagging effect according to the ultrasound results of the bile ducts and a gallbladder.