Opistorchis felineus invasion influence on immunity in bronchial asthma
https://doi.org/10.20538/1682-0363-2010-3-85-90
Abstract
To investigate the molecular mechanisms of human immune response modification by Opisthorchis felineus antigens in bronchial asthma. The experimental study was performed with cell cultures from patients with bronchial asthma, patients with opisthorchiasis, and patients with BA and opisthorchiasis co-occurred. A proposed down-regulation of immune response by higher level of IL10 and TGFB genes expression in patients with opisthorchiasis was revealed.
About the Authors
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. B. Freidin
НИИ медицинской генетики СО РАМН
Russian Federation
Russian Federation
A. E. Sazonov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
O. S. Fyodorova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
I. A. Deyev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
Ye. E. Kremer
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Бронхиальная астма у детей: диагностика, лечение и профилактика: научно-практическая программа//Союз педиатров России, Международный фонд охраны здоровья матери и ребенка. М., 2004. 46 с.
2. Бронштейн А.М., Малышев Н.А. Гельминтозы органов пищеварения: кишечные нематодозы, трематодозы печени и ларвальные цестодозы (эхинококкозы)//Рус. мед. журн. 2004. Т. 12, № 4. С. 21-23.
3. Глобальная стратегия лечения и профилактики бронхиальной астмы/под ред. А.Г. Чучалина. М.: Атмосфера, 2002. 160 с.
4. Евдокимова Т.А., Огородова Л.М. Влияние хронической описторхозной инвазии на клиническое течение и иммунный ответ при атопической бронхиальной астме у детей//Педиатрия. 2005. № 6. С. 12-14.
5. Cooper P.J. Interactions between helminth parasites and allergy//Curr. Opin. Allergy Clin. Immunol. 2009. V. 9, № 1. P. 29-37.
6. Deehan M.R., Goodridge H.S., Blair D. et al. Immunomodulatory properties of Ascaris suum glycosphingolipids-phosphorylcholine and non-phosphorylcholine-dependent effects//Parasite Immunol. 2002. V. 24, № 9-10. P. 463-469.
7. Fernando D., Wickramasinghe P., Kapilananda G. Toxocara seropositivity in Sri Lankan children with asthma//Pediatr. Int. 2009. V. 51, № 2. P. 241-245.
8. Flohr C., Quinnell R.J., Britton J. Do helminth parasites protect against atopy and allergic disease?//Clin. Exp. Allergy. 2009. V. 39, № 1. P. 20-32.
9. Hopkin J. Immune and genetic aspects of asthma, allergy and parasitic worm infections: evolutionary links//Parasite Immunol. 2009. V. 31, № 5. P. 267-273.
10. Huang S.L., Tsai P.F., Yeh Y.F. Negative association of Enterobius infestation with asthma and rhinitis in primary school children in Taipei//Clin. Exp. Allergy. 2002. V. 32. P. 1029-1031.
11. Kaewkes S. Taxonomy and biology of liver flukes//Acta Trop. 2003. V. 88, № 3. P. 177-186.
12. Leonardi-Bee J., Pritchard D., Britton J. Asthma and current intestinal parasite infection: systematic review and meta-analysis//Am. J. Respir. Crit. Care Med. 2006. V. 174, № 5. P. 514-523.
13. Medeiros M. Jr., Figueiredo J.P., Almeida M.C. et al. Schistosoma mansoni infection is associated with a reduced course of asthma//J. Allergy Clin. Immunol. 2003. V. 111. P. 947-951.
14. Ogorodova L.M., Freidin M.B., Sazonov A.E. et al. A pilot screening of prevalence of atopic states and opisthorchosis and their relationships in people of Tomsk oblast//Parasitology Research. 2007. N5. P. 80-83.
15. Oliveira R.R., Gollob K.J., Figueiredo J.P. et al. Schistosoma mansoni infection alters co-stimulatory molecule expression and cell activation in asthma//Microbes. Infect. 2009. V. 11, № 2. P. 223-229.
16. Sripa B. Pathobiology of opisthorchiasis//Acta Trop. 2003. V. 88, № 3. P. 209-220.
17. Wongratanacheewin S., Sermswan R.W., Sirisinha S. Immunology and molecular biology of Opisthorchis viverrini infection//Acta Trop. 2003. V. 88, № 3. P. 195-207.
Review
For citations:
Ogorodova L.M., Freidin M.B., Sazonov A.E., Fyodorova O.S., Deyev I.A., Kremer Ye.E. Opistorchis felineus invasion influence on immunity in bronchial asthma. Bulletin of Siberian Medicine. 2010;9(3):85-90. (In Russ.) https://doi.org/10.20538/1682-0363-2010-3-85-90
Views:
568
Email this article 