Индуцированная иммуносупрессия в критических состояниях: диагностические возможности в клинической практике
https://doi.org/10.20538/1682-0363-2019-1-18-29
Аннотация
Иммунная система в критических состояниях инициирует локальное воспаление в области повреждения, при дисбалансе местных и системных реакций воспаления инфекционного или неинфекционного генеза развивается системный воспалительный ответ, который характеризуется стадийностью «гипервоспаление – компенсаторная антивоспалительная реакция» с вероятным исходом в полиорганную недостаточность. Финальная стадия критического состояния, следовательно, будет характеризоваться индуцированной иммуносупрессией с нарушением функции нейтрофилов, моноцитов и макрофагов, дендритных клеток, выбросом супрессорных клеток миелоидного происхождения. Цель обзора – оценка вклада различных компонентов иммунной реакции в формирование индуцированной иммунной супрессии с позиции кандидатных диагностических маркеров.
Ключевые слова
Об авторах
Е. В. ГригорьевРоссия
Григорьев Евгений Валерьевич, доктор медицинских наук, профессор, заместитель директора по научной и лечебной работе, ведущий научный сотрудник, НИИ КПССЗ; заведующий кафедрой анестезиологии и реаниматологии, КемГМУ
650002, г. Кемерово, Сосновый бульвар, 6,
650000, г. Кемерово, ул. Ворошилова, 22
В. Г. Матвеева
Россия
Матвеева Вера Геннадьевна, кандидат медицинских наук, старший научный сотрудник, лаборатория клеточных технологий, НИИ КПССЗ
650002, г. Кемерово, Сосновый бульвар, 6
Д. Л. Шукевич
Россия
Шукевич Дмитрий Леонидович, доктор медицинских наук, заведующий лабораторией критических состояний, НИИ КПССЗ; профессор кафедры анестезиологии и реаниматологии, КемГМУ
650002, г. Кемерово, Сосновый бульвар, 6,
650000, г. Кемерово, ул. Ворошилова, 22
А. С. Радивилко
Россия
Радивилко Артем Сергеевич, кандидат медицинских наук, старший научный сотрудник, лаборатория критических состояний
650002, г. Кемерово, Сосновый бульвар, 6
Е. А. Великанова
Россия
Великанова Елена Анатольевна, кандидат биологических наук, научный сотрудник, лаборатория клеточных технологий
650002, г. Кемерово, Сосновый бульвар, 6
М. Ю. Ханова
Россия
Ханова Марьям Юрисовна, лаборант-исследователь, лаборатория клеточных технологий
650002, г. Кемерово, Сосновый бульвар, 6
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Рецензия
Для цитирования:
Григорьев Е.В., Матвеева В.Г., Шукевич Д.Л., Радивилко А.С., Великанова Е.А., Ханова М.Ю. Индуцированная иммуносупрессия в критических состояниях: диагностические возможности в клинической практике. Бюллетень сибирской медицины. 2019;18(1):18-29. https://doi.org/10.20538/1682-0363-2019-1-18-29
For citation:
Grigoryev E.V., Matveeva V.G., Shukevich D.L., Radivilko A.S., Velikanova E.A., Khanova M.Yu. Induced immunosuppression in critical care: diagnostic opportunities in clinical practice. Bulletin of Siberian Medicine. 2019;18(1):18-29. (In Russ.) https://doi.org/10.20538/1682-0363-2019-1-18-29