OBESITY AS A RISK FACTOR FOR PULMONARY EMBOLISM
https://doi.org/10.20538/1682-0363-2014-2-10-13
Abstract
The aim of the study. Based on the data of the Register of new cases of hospital pulmonary embolism (PE) in hospitals in Tomsk (2003–2012), to explore the contribution of obesity to the development of venous thromboembolism.
Material and Methods. Study were subjected to medical history and records of autopsies of patients treated in hospitals in Tomsk in 2003–2012, who at patologoanatomic and/or instrumental study revealed pulmonary embolism. The degree of obesity was assessed according to WHO criteria (1997). Statistical processing of the results was carried out using the software package for PC Statistica 8.0 for Windows. To test the normality of the distribution of quantitative traits using the Shapiro–Wilk test and the Kolmogorov–Smirnov with the adjusted Lillieforsa. Check the equality of the population variance was performed using Fisher's exact test and Cochran. Was considered statistically significant level of p < 0.05.
The results of the study. In Western Siberia, Tomsk, a register of hospital pulmonary embolism (2003–2012). In the register included 720 patients with in vivo and/or post mortem revealed pulmonary embolism (PE). Analyzed data from medical records and autopsy reports. Revealed statistically significant differences in BMI (p = 0.033) and the presence of obesity (p = 0.002) in patients with pulmonary embolism, holding medical and surgical beds. As of medical, surgical and among patients with thromboembolism, obesity is significantly more common in women than men (p = 0.050 and p = 0.041 respectively). According to the study, obesity grade 1 or 2 alone (at the isolated presence of the patient) is not significantly increased the odds of a massive thromboembolism. However, grade 3 obesity increased the odds of a massive pulmonary embolism by more than 2.7 times (OR = 2.708, CI: 1,461–5,020).
About the Authors
O. Ya. Vasiltseva
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Vasiltseva Oksana Ya.
Russian Federation
Vasiltseva Oksana Ya.
I. N. Vorozhtsova
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Vorozhtsova Irina N.
Russian Federation
Vorozhtsova Irina N.
R. S. Karpov
Institute of Cardiology, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Karpov Rostislav S.
Russian Federation
Karpov Rostislav S.
References
1. Torbicki A., Perrier A., Konstantinides S. et al. Guid elines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). European Heart Journal, 2008, Aug., vol. 29, no. 18, pp. 2276–2315. doi:10.1093/eurheartj/ehn310. Epub. 2008. Aug. 30.
2. Tleubayeva N.V. Pathogenetic aspects of postoperative thrombotic complications in deforming arthrosis. Author. Dis. Cand. Med. Sci. Kemerovo, 2009. 23 p. (in Russian).
3. Pomp Elisabeth R., Saskia le Cessie, Rosendaal Frits R., Carine J.M. Doggen. Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations. British Journal of Haematology, 2007, Oct., vol. 139, no. 2, pp. 289–296. doi: 10.1111/j.13652141.2007.06780.x 2007. 25 Sep.
4. Dedov I.I., Melnichenko G.A., Bugrova S.A. Obesity and Metabolism, 2006, no. 1, pp. 6–13 (in Russian).
5. Ametov A.S. Obesity is an epidemic of the XXI century. Therapeutic Archive, 2002, no. 10, pp. 5–7 (in Russian).
6. Sanjeev Sabharwal, Michael Z. Root Impact of Obesity on Orthopaedics. J. Bone. Joint. Surg. Am., 2012, Jun., vol. 94, no. 11, pp. 1045–1052. doi: 10.2106/JBJS.K.00330.
7. Fadeyenko G.D., Maslyayeva L.V. Pharmaceuticals of Ukraine, 2009, vol. 132, no. 6, pp. 31–37 (in Ukrainian).
8. Gilyarevsky S.R. Heart, 2009, vol. 8, no. 5, pp. 270–288 (in Russian).
9. Okamoto Y., Arita Y., Nishida M. et al. An adipocyte-derived plasma protein, adiponectin, adheres to injures vascular walls. Horm. Metab. Res., 2000, vol. 32, no. 4, pp. 47.
10. Mallamaci F., Zoccali C., Cuzzola F. et al. Adiponectin and essential hypertension. J. Nephrol., 2002, vol. 15, no. 2, pp. 507–511.
11. Matsuzawa Y., Funahashi T., Kihara S., Shimomura I. Adiponectin and Metabolic Syndrome. Arterioscler. Thromb. Vasc. Biol., 2004, vol. 24, no. 3, pp. 29–33.
12. Mertens I., Van Gaal L.F. Obesity, haemostasis and the fibrinolytic system. Obes. Rev., 2002, vol. 3, no. 2, pp. 85–101.
13. Margaglione M., Cappucci G., d’Addedda M. et al. PAI-1 plasma levels in a general population without clinical evidence of atherosclerosis: relation to environmental and genetic determinants. Arterioscler. Thromb. Vasc. Biol., 1998, vol. 18, no. 4, pp. 562.
14. Kaelber D.C., Foster W., Gilder J., Love T.E., Jain A.K. Patient characteristics associated with venous thromboembolicevents: a cohort study using pooled electronic health record data. J. Am. Med. Inform. Assoc., 2012, vol. 19, no. 3, pp. 965–972. doi:10.1136/amiajnl-2011-000782.
15. Rocha A.T., de Vasconcellos Â.G., da Luz Neto E.R., Araújo D.M.A., Alves E.S., Lopes A.A. Risk of Venous Thromboembolism and Efficacy of Thromboprophylaxis in Hospitalized Obese Medical Patients and in Obese Patients Undergoing Bariatric Surgery. Obesity Surgery, 2006, Dec., vol. 16, no. 12, pp. 1645–1655.
Review
For citations:
Vasiltseva O.Ya., Vorozhtsova I.N., Karpov R.S. OBESITY AS A RISK FACTOR FOR PULMONARY EMBOLISM. Bulletin of Siberian Medicine. 2014;13(2):10-13. (In Russ.) https://doi.org/10.20538/1682-0363-2014-2-10-13
Views:
1245
Email this article 