Механизмы нарушения контроля бронхиальной астмы при применении β2-агонистов
https://doi.org/10.20538/1682-0363-2006-1-67-72
Аннотация
Несмотря на исключительно высокую клиническую эффективность β2-агонистов при бронхоспазме, регулярное их применение ассоциировано со снижением уровня контроля бронхиальной астмы и развитием тяжелых и жизнеугрожающих состояний, что связано с повышением бронхиальной гиперреактивности, развитием частичной толерантности, повышенной аллергенной нагрузкой и маскировкой симптомов ухудшения заболевания. Развитие толерантности к β2-агонистам и повышение чувствительности бронхов к бронхоконстрикторным стимулам имеют в своей основе специфические механизмы, включая десенситизациию β2-адренорецептора, увеличение экспрессии фосфолипазы-Cβ и до конца не изученные механизмы, связанные с вариантами гена β2-АР.
Ключевые слова
616.248:615.234
Об авторах
Н. В. Васьковский
Сибирский государственный медицинский университет
Россия
Россия
Е. С. Куликов
Сибирский государственный медицинский университет, г. Томск
Россия
Россия
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Рецензия
Для цитирования:
Васьковский Н.В., Куликов Е.С. Механизмы нарушения контроля бронхиальной астмы при применении β2-агонистов. Бюллетень сибирской медицины. 2006;5(1):67-72. https://doi.org/10.20538/1682-0363-2006-1-67-72
For citation:
Vas'kovsky N.V., Koulikov Y.S. Mechanisms of bronchial asthma control disturbance in using 2-agonists. Bulletin of Siberian Medicine. 2006;5(1):67-72. (In Russ.) https://doi.org/10.20538/1682-0363-2006-1-67-72
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